What is Invokana used for and how does it work?
Key Points
Invokana is not used in patients with type 1 diabetes or diabetic ketoacidosis (increased ketones in blood or urine).
Invokana carries a boxed warning of a greater risk for lower limb amputations, which may involve the toe, foot and leg. In studies, some patients had multiple amputations, some involving both limbs. Your doctor will monitor you for infections of ulcers of the lower limbs, and may need to stop treatment.
You may be at a higher risk of lower limb amputation if you:
Who should not use Invokana?
You should not used Invokana if:
Your doctor will check your kidney function before you begin treatment with Invokana.
What is the mechanism of action for Invokana?
Invokana is classified as an SGLT-2 (sodium-glucose co-transporter-2) inhibitor. Sodium-glucose co-transporter-2 (SGLT-2) proteins are found in the kidneys and are responsible for reabsorbing glucose (sugar) back into the blood.
Invokana blocks the function of the SGLT-2 proteins which results in more glucose being excreted in the urine.
SGLT-2 inhibitors are effective at lowering hemoglobin A1C levels, improving weight loss and lowering blood pressure. They carry a low risk of hypoglycemia (low blood sugar levels) when used alone.
Other FDA-approved medications in the SGLT-2 inhibitor class include empagliflozin (Jardiance), dapagliflozin (Farxiga), and ertugliflozin (Steglatro). These medicines come as single-ingredient products or combined with other diabetes medications.
How does Invokana treat my type 2 diabetes?
Patients living with type 2 diabetes:
A build-up of blood sugar can lead to serious health concerns with your heart, kidney, nerves, blood vessels and eyes. An appropriate diet, exercise and use of prescription medications such as Invokana may help to lower your blood sugar and health risks from type 2 diabetes.
Invokana can help you reach your A1C goal. A1C is a simple blood test that shows the average amount of sugar (glucose) in your blood over the past 2 to 3 months, letting you know how well your blood sugar is being controlled over time.
If needed, Invokana can also be used with other medications such as metformin to help control your blood sugar.
Invokana is not approved as a weight loss treatment, but in some people with type 2 diabetes, Invokana can lead to a 2% to 3% weight reduction. Your specific results may vary depending upon your dose or if you take other diabetes medicines.
When is the best time to take Invokana?
Invokana is normally taken once a day before your first meal of the day.
Always take your medicine exactly how your doctor tells you to take it. Your doctor may need to change your dose or you may need to use Invokana with other medications.
When Invokana is used with other drugs that also lower blood sugar, such as insulin or sulfonylureas, a risk of low blood sugar (hypoglycemia) is possible. Know how to recognize the signs and symptoms of low blood sugar.
What should I do if I miss my dose of Invokana?
Bottom Line
Invokana is used to help you manage your blood sugar if you have type 2 diabetes. It can also help to protect your kidneys and lower your risk for heart-related hospitalization or death.
In patients with type 2 diabetes, Invokana works by blocking certain proteins in the kidney that absorb sugar back into the blood. It increases the amount of sugar that is excreted in your urine.
Invokana can be added to other types of medicines for type 2 diabetes, including metformin, to help you to meet your goals. You and your doctor will determine your best treatment option based on your condition, medical history, side effects and cost.
This is not all the information you need to know about Invokana for safe and effective use. Review the full Invokana information here, and speak to your health care provider if you have questions or concerns.
Related medical questions
- Can Januvia and Invokana be taken together?
- What are the dangers / risks of Invokana?
- Does Invokana cause weight loss?
- When is the best time to take Invokana?
- How long does it take for Invokana to work?
- What is Invokana used for and how does it work?
- Is it safe to take Invokana?
- How effective Is Invokana?
- Can Januvia and Invokana be taken together?
- What are the dangers / risks of Invokana?
- Does Invokana cause weight loss?
- When is the best time to take Invokana?
- How long does it take for Invokana to work?
- What is Invokana used for and how does it work?
- Is it safe to take Invokana?
- How effective Is Invokana?
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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