What is the difference between Leqvio and Repatha?

Official answer

by Drugs.com

Leqvio and Repatha are both injectable medicines that are used for the treatment of high cholesterol, by specifically lowering low density lipoprotein (HDL) levels. Although they both inhibit PCSK9 they work by different mechanisms. Repatha is a monoclonal antibody that binds directly to PCSK9 in the liver preventing it from binding to LDL receptors. Leqvio blocks the PCSK9 protein by interfering with the translation of PCSK9 messenger RNA. Both have the same result – and that is freeing up LDL receptors on the surface of liver cells which allows LDL cholesterol to be removed from the blood.

Related medical questions

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• What are PCSK9 Inhibitors and how do they work?
• What is the difference between Leqvio and Repatha?
• Can Leqvio be taken without a statin?
• Does Leqvio cause weight gain?
• How is Leqvio injection administered?
• What is the mechanism of action for Leqvio (inclisiran)?
• Is Leqvio FDA approved as a high cholesterol treatment?
• Who is the actor in the Leqvio commercial?
• Where can I find the Leqvio FDA package insert?

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