When was the Probuphine implant discontinued?

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Official answer

by Drugs.com

Probuphine implant was discontinued by Titan Pharmaceuticals in October 2020 and no generic is available in the US. In former studies, roughly two-thirds of Probuphine-treated patients had no evidence of illicit opioid use throughout the six months of treatment – similar to the number of those who responded to sublingual (under the tongue) buprenorphine alone.

Contact the manufacturer for more information at 1-650-244-4990.

Other long-acting buprenorphine products for opioid use disorder exist in different dosage forms:

  • Sublocade is an extended-release, once-monthly depot injection currently available from Indivior.
  • Brixadi, from Braeburn, has been tentatively approved by the FDA, but is not yet available on the market. Brixadi is a long-acting, extended-release buprenorphine injection given either weekly or monthly for the treatment of opioid use disorder (OUD).

    • In May 2016 the FDA approved Probuphine (buprenorphine) implant for the maintenance treatment of opioid dependence. Probuphine consisted of four, one-inch-long rods that were implanted under the skin in the upper arm to provide a constant, low-level dose of buprenorphine for six months.

    Probuphine was used as part of a complete opioid dependence treatment program including counseling and psychosocial support. Buprenorphine is classified as a opioid partial agonist.

    Advantages to buprenorphine intradermal implants were a longer duration of action and improved patient compliance because there was no need to remember to take a daily medicine. In addition, other dose forms of buprenorphine, such sublingual pills or buccal films may be lost, forgotten or stolen.

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