Advanced Cardiovascular-Kidney-Metabolic Risk Linked to Increased Cancer Risk

Follow Drugslib on

By Elana Gotkine HealthDay Reporter

Medically reviewed by Carmen Pope, Senior Medical Editor, B. Pharm. Last updated on April 27, 2026.

via HealthDay

MONDAY, April 27, 2026 -- Advanced cardiovascular-kidney-metabolic (CKM) syndrome stage, especially stages 3 and 4, is associated with increased cancer risk, according to a study published online April 27 in Circulation: Population Health and Outcomes.

Tatsuhiko Azegami, M.D., Ph.D., from the Keio University School of Medicine in Tokyo, and colleagues conducted a retrospective cohort study using an administrative claims database to examine the longitudinal association between CKM stage and cancer risk. A total of 1,390,901 individuals were included after excluding those with prior cancer or missing covariates.

The researchers found that higher baseline CKM stages were associated with increased cancer risk during a median follow-up of 3.4 years. For CKM stages 1 to 4, compared with 0, the adjusted hazard ratios (95 percent confidence intervals) were 1.03 (0.99 to 1.08), 1.02 (0.99 to 1.05), 1.25 (1.21 to 1.29), and 1.30 (1.25 to 1.35), respectively. Across cancer types and in analyses stratified by age and sex, the stage-specific association was consistent, with similar patterns seen across subgroups. The robustness of the findings was supported in sensitivity analyses using alternative CKM definitions.

"The study findings suggest that it is important to consider not only cardiovascular disease risk, but also cancer risk in people with CKM syndrome," lead author Hidehiro Kaneko, M.D., Ph.D., from the University of Tokyo, said in a statement.

Several authors disclosed ties to the health technology industry.

Abstract/Full Text

Editorial

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

Source: HealthDay

Posted : 2026-04-28 02:13

Read more

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Popular Keywords