AI Model Can Optimize, Standardize Total Parenteral Nutrition Formulas
By Elana Gotkine HealthDay Reporter
TUESDAY, April 1, 2025 -- An artificial intelligence (AI) approach identified total parenteral nutrition (TPN) formulas that increase safety and potentially reduce costs for neonates admitted to neonatal intensive care units, according to a study published online March 25 in Nature Medicine.
Thanaphong Phongpreecha, from Stanford University in California, and colleagues developed TPN2.0, a data-driven approach that optimizes and standardizes TPN using information obtained from electronic health records. To train TPN2.0, TPN compositions from a decade were assembled (79,790 orders; 5,913 patients). The model was also validated in an external cohort (63,273 orders; 3,417 patients) from a second hospital.
The researchers identified 15 TPN formulas that can enable a precision-medicine approach using the algorithm (Pearson's R = 0.94 compared to experts), which increased safety and potentially reduced costs. In a blinded study of 192 neonates, TPN2.0 was rated higher than current best practice by physicians. In patients with high disagreement between actual prescriptions and TPN2.0, increased morbidities were seen in association with standard prescriptions (e.g., odds ratio 3.33 for necrotizing enterocolitis), while a reduced risk was seen with TPN2.0 recommendations. Guideline-adhering, physician-in-the-loop recommendations were enabled by TPN2.0 employing a transformer architecture, allowing collaboration between the care team and AI.
"Taken together, TPN2.0 demonstrates the potential of AI to go beyond predictive diagnosis and guide a key therapeutic decision for newborns in the most vulnerable time of their lives," the authors write.
Several authors disclosed ties to the biopharmaceutical industry; the methods described in this study are covered in a U.S. provisional patent.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
Source: HealthDay
Posted : 2025-04-02 06:00
Read more

- Ground Coffee Recalled in 15 States for Caffeine Labeling Error
- Sugar Substitute Appears To Boost Appetite, Hunger
- Oklahoma Now Reporting Measles Cases Related to Texas/New Mexico Outbreak
- Botox Intervention Improves Facial Asymmetry After Nerve Damage
- Novartis Receives Third FDA Approval for Oral Fabhalta (iptacopan), the First and Only Treatment Approved in C3 Glomerulopathy
- Women More Vulnerable To Heart Risk Factors
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Popular Keywords
- metformin obat apa
- alahan panjang
- glimepiride obat apa
- takikardia adalah
- erau ernie
- pradiabetes
- besar88
- atrofi adalah
- kutu anjing
- trakeostomi
- mayzent pi
- enbrel auto injector not working
- enbrel interactions
- lenvima life expectancy
- leqvio pi
- what is lenvima
- lenvima pi
- empagliflozin-linagliptin
- encourage foundation for enbrel
- qulipta drug interactions