ASA: Intra-Arterial Tenecteplase Beneficial for Large Vessel Occlusion

Follow Drugslib on

Medically reviewed by Carmen Pope, BPharm. Last updated on Feb 18, 2025.

By Elana Gotkine HealthDay Reporter

TUESDAY, Feb. 18, 2025 -- For patients with large vessel occlusion presenting between 4.5 and 24 hours, intra-arterial tenecteplase after successful thrombectomy results in improved likelihood of excellent outcome (modified Rankin scale score 0 to 1), according to a study presented at the annual American Stroke Association International Stroke Conference, held from Feb. 5 to 7 in Los Angeles.

Xiaochuan Huo, M.D., Ph.D., from Beijing Anzhen Hospital, and colleagues conducted a multicenter, prospective, randomized trial involving patients with acute anterior circulation large vessel occlusion treated between 4.5 and 24 hours from the time last known to be well. After successful endovascular recanalization, patients were randomly assigned to receive intra-arterial tenecteplase or standard medical management (127 and 129 participants, respectively).

The researchers found that the percentage of patients with a modified Rankin scale score of 0 or 1 at 90 days was higher with intra-arterial tenecteplase versus standard medical treatment after endovascular therapy (40.5 versus 26.4 percent; relative rate, 1.44; 95 percent confidence interval, 1.06 to 1.95). Mortality at 90 days did not differ significantly between the groups and was 21.4 and 21.7 percent with intra-arterial tenecteplase and standard medical treatment, respectively. There was no significant difference seen in the incidence of symptomatic intracranial hemorrhage within 48 hours after treatment (5.6 and 6.2 percent with intra-arterial tenecteplase and standard medical treatment, respectively).

"Intra-arterial tenecteplase after successful thrombectomy could improve the percentage of people with an excellent outcome," Huo said in a statement. "It could also improve the rate of large vessel occlusion stroke survivors who can return to society and live independently."

Press Release

More Information

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

Source: HealthDay

Posted : 2025-02-19 06:00

Read more

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Popular Keywords