ASCO: Durvalumab Plus FLOT Beneficial for Resectable Gastric, GE Junction Cancer

Follow Drugslib on

Medically reviewed by Carmen Pope, BPharm. Last updated on June 5, 2025.

By Elana Gotkine HealthDay Reporter

THURSDAY, June 5, 2025 -- For patients with resectable gastric or gastroesophageal junction adenocarcinoma, durvalumab plus fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) yields better event-free survival outcomes than FLOT alone, according to a study published online June 1 in the New England Journal of Medicine. The research was published to coincide with the annual meeting of the American Society of Clinical Oncology, held from May 31 to June 4 in Chicago.

Yelena Y. Janjigian, M.D., from Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine in New York City, and colleagues conducted a phase 3, double-blind, randomized trial involving patients with resectable gastric or gastroesophageal junction adenocarcinoma. Participants were randomly assigned to receive durvalumab (1,500 mg) or placebo every four weeks plus FLOT for four cycles, followed by 10 cycles of durvalumab or placebo every four weeks (474 patients to each group). Event-free survival was the primary end point.

The researchers found that the two-year event-free survival was 67.4 and 58.5 percent among those in the durvalumab and placebo groups, respectively (hazard ratio for event or death: 0.71; 95 percent confidence interval, 0.58 to 0.86; P < 0.001). Two-year overall survival was 75.7 and 70.4 percent in the durvalumab and placebo groups, respectively (piecewise hazard ratio for death during months 0 to 12: 0.99; 95 percent confidence interval, 0.70 to 1.39; piecewise hazard ratio for death during the period from month 12 onward: 0.67; 95 percent confidence interval, 0.50 to 0.90; P = 0.03 by a stratified log-rank test [exceeding the significance threshold of P < 0.0001]). The percentage of patients with a pathological complete response was 19.2 and 7.2 percent in the durvalumab and placebo groups, respectively (relative risk: 2.69; 95 percent confidence interval, 1.86 to 3.90).

“This is a major step forward for patients facing this difficult diagnosis,” Janjigian said in a statement. “To be able to tell a patient that their cancer has completely responded to treatment -- and that they are cured -- is one of the most rewarding moments in oncology. These results bring us closer to making that outcome a reality for many more patients worldwide.”

Several authors disclosed ties to biopharmaceutical companies, including AstraZeneca, which manufactures durvalumab and funded the trial.

Abstract/Full Text (subscription or payment may be required)

More Information

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

Source: HealthDay

Posted : 2025-06-06 06:00

Read more

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Popular Keywords