ASN: Empagliflozin Offers Lasting Cardiorenal Benefit in CKD Patients

Follow Drugslib on

Medically reviewed by Judith Stewart, BPharm. Last updated on Oct 28, 2024.

By Elana Gotkine HealthDay Reporter

MONDAY, Oct. 28, 2024 -- Empagliflozin continues to offer cardiorenal benefits for up to 12 months after discontinuation among patients with chronic kidney disease at risk for progression, according to a study published online Oct. 25 in the New England Journal of Medicine to coincide with Kidney Week, the annual meeting of the American Society of Nephrology, held from Oct. 23 to 27 in San Diego.

William G. Herrington, M.B.B.S., from the University of Oxford in the United Kingdom, and colleagues randomly assigned 6,609 patients with chronic kidney disease to receive empagliflozin (10 mg once daily) or matching placebo and followed them for a median of two years in an active trial. Surviving patients who consented were observed for an additional two years (4,891 patients enrolled [74 percent]). During the posttrial period, no trial empagliflozin or placebo was administered, but local practitioners could prescribe open-label sodium-glucose cotransporter 2 (SGLT2) inhibitors, including open-label empagliflozin.

The researchers found that the use of open-label SGLT2 inhibitors was similar in the two groups during the posttrial period (43 and 40 percent in the empagliflozin and placebo groups, respectively). A primary outcome event (kidney disease progression or cardiovascular death) occurred in 26.2 and 30.3 percent of patients in the empagliflozin and placebo groups, respectively, during the combined active-trial and posttrial periods (hazard ratio, 0.79). The hazard ratio for a primary outcome event during the posttrial period only was 0.87.

"In a broad range of patients with chronic kidney disease, empagliflozin continued to have additional cardiorenal benefits for up to 12 months after it was discontinued," the authors write.

Several authors disclosed ties to pharmaceutical companies, including Boehringer Ingelheim and Eli Lilly, which manufacture empagliflozin and funded the study.

Abstract/Full Text (subscription or payment may be required)

More Information

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

Source: HealthDay

Posted : 2024-10-29 06:00

Read more

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Popular Keywords