Botulinum Toxin May Be Beneficial for Isolated, Essential Head Tremor
By Elana Gotkine HealthDay Reporter
THURSDAY, Nov. 9, 2023 -- For patients with isolated or essential head tremor, injection of botulinum toxin into each splenius capitis muscle on day 0 and during week 12 is more effective than placebo for reducing tremor severity, according to a study published in the Nov. 9 issue of the New England Journal of Medicine.
Ana Marques, M.D., Ph.D., from Université Clermont-Auvergne in France and colleagues enrolled adult patients with essential or isolated head tremor in a multicenter trial. A total of 117 patients were randomly assigned to receive botulinum toxin type A or placebo (62 and 55 patients, respectively) injected under electromyographic guidance into each splenius capitis muscle on the day of randomization (day 0) and during week 12, and were included in the intention-to-treat analysis.
The researchers found that improvement of at least 2 points on the Clinical Global Impression of Change (CGI) scale at week 6 after the second injection (week 18) occurred in 31 and 9 percent of patients in the botulinum toxin and placebo groups, respectively (relative risk, 3.37). At six and 12, but not 24 weeks, analyses of secondary outcomes were generally supportive of the primary outcome analysis. About half of the patients in the botulinum toxin group had adverse events, including head and neck pain, posterior cervical weakness, and dysphagia.
"The percentage of patients with improvement in head tremor, prespecified as improvement by at least two points on the CGI scale at week 18 (primary outcome), was higher in the botulinum toxin group than in the placebo group," the authors write.
Several authors disclosed ties to the pharmaceutical industry.
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
Source: HealthDay
Posted : 2023-11-10 01:09
Read more

- Urine Test Sensitive for Renal Cancer Recurrence After Surgery
- Ovarian Cancer Test May Miss Black and Native American Patients
- Poll Reveals Only 17 Percent Think Medicaid Funding Should Be Cut
- Eneboparatide Met Primary Endpoint of Normalising Serum Calcium in Adults with Hypoparathyroidism at 24 weeks in CALYPSO Phase III Trial
- The United Laboratories and Novo Nordisk Announce Exclusive License Agreement for UBT251, a GLP-1/GIP/Glucagon Triple Receptor Agonist
- Swallowing Disorder Not Widely Known, Understood By Public
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Popular Keywords
- metformin obat apa
- alahan panjang
- glimepiride obat apa
- takikardia adalah
- erau ernie
- pradiabetes
- besar88
- atrofi adalah
- kutu anjing
- trakeostomi
- mayzent pi
- enbrel auto injector not working
- enbrel interactions
- lenvima life expectancy
- leqvio pi
- what is lenvima
- lenvima pi
- empagliflozin-linagliptin
- encourage foundation for enbrel
- qulipta drug interactions