Breast Cancer Risk Elevated With Levonorgestrel-Releasing Intrauterine System Use

Follow Drugslib on

Medically reviewed by Carmen Pope, BPharm. Last updated on Oct 18, 2024.

By Elana Gotkine HealthDay Reporter

FRIDAY, Oct. 18, 2024 -- Women using levonorgestrel-releasing intrauterine systems (LNG-IUS) have an increased risk for breast cancer, according to a study published online Oct. 16 in the Journal of the American Medical Association.

Lina Steinrud Mørch, Ph.D., from the Danish Cancer Institute in Copenhagen, Denmark, and colleagues examined breast cancer risk with continuous use of an LNG-IUS using data from nationwide Danish registers. All first-time initiators of any LNG-IUS aged 15 to 49 years in 2000 to 2019 were identified and matched to nonusers of hormonal contraceptives on the date of initiation (index date). The association between continuous LNG-IUS and breast cancer was examined, adjusting for confounding variables.

The analysis included 78,595 new LNG-IUS users and 78,595 nonusers of hormonal contraceptives. The researchers found that 1,617 participants were diagnosed with breast cancer during a mean follow-up of 6.8 years: 720 LNG-IUS users and 897 nonusers. The hazard ratio for breast cancer was 1.4 for LNG-IUS use versus nonuse. The hazard ratios were 1.3, 1.4, and 1.8 for zero to five, five to 10, and more than 10 to 15 years of use, respectively, compared with the corresponding durations of nonuse, resulting in an excess of 14, 29, and 71 breast cancer diagnoses per 10,000 users (P = 0.15 for trend).

"Given the increase in LNG-IUS use among females at an age with some risk for breast cancer, and its likely long-term use, information about breast cancer risk should accompany discussions about benefits and risks," the authors write.

Abstract/Full Text (subscription or payment may be required)

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

Source: HealthDay

Posted : 2024-10-19 06:00

Read more

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Popular Keywords