Calculator Can Help Tailor Treatment During, After Heart Pump Placement

Follow Drugslib on

Medically reviewed by Drugs.com.

By Elana Gotkine HealthDay Reporter

MONDAY, Feb. 5, 2024 -- The right ventricular failure (RVF) risk score, STOP-RVF calculator, can predict RVF after durable left ventricular assist device (LVAD) placement, according to a study published online Jan. 31 in JAMA Cardiology.

Iosif Taleb, M.D., from the University of Utah Health and School of Medicine in Salt Lake City, and colleagues derived and validated a risk model to predict RVF after LVAD implantation. Patients with advanced heart failure enrolled at five institutions were included in the derivation cohort (798 patients); patients enrolled at a sixth institution were included as the external validation cohort (327 patients). Several techniques were used to derive a predictive model; the RVF risk calculator (STOP-RVF) was developed and validated externally.

The researchers found that RVF developed in 24.2 and 32.7 percent of patients in the derivation and validation cohorts, respectively. Preimplant variables associated with postoperative RVF included nonischemic cardiomyopathy, intra-aortic balloon pump, microaxial percutaneous left ventricular assist device/venoarterial extracorporeal membrane oxygenation, and LVAD configuration. Model performance was not improved with inclusion of intraoperative variables. The C-statistic for the calculator was 0.75 and 0.73 in the derivation and validation cohorts, respectively. Patients comprising the low-risk group (estimated <20 percent RVF risk) had higher cumulative survival than those in the high-risk group. The STOP-RVF risk score exhibited significantly better performance than commonly used risk scores.

"The calculator could impact the selection of patients with both acute and chronic advanced heart failure undergoing advanced therapies evaluation, as well as assist in their perioperative optimization to reduce RVF-related morbidity and mortality," the authors write.

Several authors disclosed ties to the pharmaceutical and medical device industries.

Abstract/Full Text (subscription or payment may be required)

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

Source: HealthDay

Posted : 2024-02-06 00:15

Read more

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Popular Keywords