Cannabis Use Disorder May Up Risk of Benign Salivary Gland Tumors

Follow Drugslib on

By Elana Gotkine HealthDay Reporter

Medically reviewed by Carmen Pope, BPharm. Last updated on July 21, 2025.

via HealthDay

MONDAY, July 21, 2025 -- Cannabis use disorder (CUD) is associated with increased risk of benign salivary gland tumors, according to a research letter published online July 17 in JAMA Otolaryngology-Head & Neck Surgery.

Tyler J. Gallagher, M.D., M.P.H., from the Keck School of Medicine at the University of Southern California in Los Angeles, and colleagues conducted a retrospective cohort study using deidentified data from the TriNetX U.S. Collaborative Network to examine the association between cannabis use and benign salivary gland tumors. Two cohorts of adults age 18 years or older were created: one had a diagnosis of cannabis-related disorder and the other had no cannabis-related disorder diagnosis between Jan. 24, 2005, and Jan. 24, 2025.

The researchers found that the incidence of any benign major salivary gland tumor was higher in the group with CUD (183,818 individuals) than the group without CUD (6,248,964 individuals) (0.08 versus 0.02 percent). The group with versus without CUD also had higher incidence of benign parotid salivary gland tumors (0.05 versus 0.01 percent). After propensity score matching, the relative risk of any benign major salivary gland tumor was higher among those with versus without CUD at all time points (relative risks, 5.18, 4.32, and 5.00 at any time, zero to less than five years, and at five or more years, respectively) after CUD diagnosis or outpatient hospital visit. Elevated relative risk of a benign parotid salivary gland tumor was also seen (relative risks, 5.16, 4.92, and 3.90 for any time, zero to less than five years, and five or more years, respectively).

"The elevated relative risk of benign parotid tumors and the persistent association over time highlight potential site-specific outcomes of cannabis use," the authors write.

Abstract/Full Text (subscription or payment may be required)

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

Source: HealthDay

Posted : 2025-07-22 06:00

Read more

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Popular Keywords