Device-Driven, Nurse-Led Intervention Safe but Neutral for Heart Failure Outcomes

Follow Drugslib on

By Elana Gotkine HealthDay Reporter

Medically reviewed by Judith Stewart, BPharm. Last updated on May 29, 2026.

via HealthDay

FRIDAY, May 29, 2026 -- For patients with heart failure, insertable cardiac monitor (ICM)-based high-risk detection combined with centrally managed, nurse-facilitated, individually protocolized diuretic interventions are safe but did not lead to a change in heart failure outcomes, according to a study published online May 27 in the Journal of the American College of Cardiology.

Javed Butler, M.D., M.P.H., from the Baylor Scott and White Research Institute in Dallas, and colleagues examined whether ICM-based high-risk detection combined with centrally managed, nurse-facilitated, individually protocolized diuretic interventions are safe and improve heart failure outcomes. Participants with heart failure were randomly assigned to an intervention arm (high-risk heart failure alert-triggering protocolized diuretic regimen) or an observation arm (standard care; 357 and 354 participants, respectively).

The researchers found that 59.9 percent of participants had at least one high-risk episode in the randomized period, including 54.4 percent of those with left ventricular ejection fraction <50 percent and 62.5 percent with heart failure with preserved ejection fraction. The primary composite efficacy end point did not differ significantly between the groups (win ratio: 0.79; 95 percent confidence interval, 0.62 to 1.01; P = 0.06). The serious adverse events rate was 0.32 percent during a mean follow-up of 17.3 ± 8.9 months (prespecified safety threshold ≤5 percent). The intervention group had numerically higher cumulative cardiovascular death and heart failure events (hazard ratio, 1.43; 95 percent confidence interval, 0.95 to 2.15; P = 0.091). At 13 months after randomization, 67.2 percent of participants had a device-detected arrhythmia.

"These insights from the ALLEVIATE-HF clinical trial have brought to light a striking burden of clinically meaningful arrhythmias in a broad group of symptomatic heart failure patients, which until this point, had been underappreciated," coauthor Rami Kahwash, M.D., from The Ohio State University Wexner Medical Center in Columbus, said in a statement.

Several authors disclosed ties to biopharmaceutical and medical technology companies, including Medtronic, which funded the study.

Abstract/Full Text

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

Source: HealthDay

Posted : 2026-05-30 03:14

Read more

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Popular Keywords