Estrogen-Linked Thrombotic Biomarkers Drop After Cessation of Combo Pill

Follow Drugslib on

Medically reviewed by Carmen Pope, BPharm. Last updated on Nov 15, 2023.

By Elana Gotkine HealthDay Reporter

TUESDAY, Nov. 14, 2023 -- Cessation of combined hormonal contraceptives (CHC) is associated with a rapid decline in estrogen-related thrombotic biomarkers, according to a study published online Nov. 8 in Blood.

Justine Hugon-Rodin, M.D., Ph.D., from the Hospital Saint Joseph in Paris, and colleagues conducted a prospective cohort study to define the time until normalization of the estrogen-related thrombotic biomarkers after CHC cessation. Women aged 18 to 50 years who had decided to stop their CHC were enrolled. The study started six weeks before CHC cessation and included six visits afterward up to 12 weeks after cessation.

The researchers found that from baseline to week 12, there were decreases in the average levels of normalized sensitivity ratios to activated protein C (4.11 to 1.27 nmol/L), thrombomodulin (2.53 to 1.11 nmol/L), and sex hormone-binding globulin (167 to 55.4 nmol/L) among 66 users of CHC. Overall, 85.8, 81.3, and 76.2 percent and 86.7, 85.5, and 87.8 percent of the decrease from baseline to week 12 was achieved at two and four weeks after CHC cessation, respectively. Among 28 control women, levels were not meaningfully modified throughout the study.

"It's reassuring to know that that possible harm of the pill goes away rapidly when one stops taking it," coauthor Marc Blondon, M.D., from the University Hospitals of Geneva, said in a statement.

Abstract/Full Text (subscription or payment may be required)

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

Source: HealthDay

Posted : 2023-11-15 09:14

Read more

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Popular Keywords