Flares Occur Frequently in Generalized Pustular Psoriasis

Follow Drugslib on

Medically reviewed by Carmen Pope, BPharm. Last updated on April 16, 2025.

By Elana Gotkine HealthDay Reporter

WEDNESDAY, April 16, 2025 -- Patients with generalized pustular psoriasis (GPP) experience frequent flares, and treatment alterations of off-label agents are frequently observed, according to a study recently published online in the Journal of the American Academy of Dermatology.

Jamie L.W. Rhoads, M.D., from the University of Utah School of Medicine in Salt Lake City, and colleagues characterized patients by GPP flare status, quantified flare timing/frequency, and examined periflare treatment patterns in a cohort study using electronic health records from 2017 to 2023 from outpatient dermatology clinics. Patients were indexed at first GPP diagnosis code.

The researchers found that 404 of the 638 patients (63 percent) experienced one or more flare episodes. The likelihood of experiencing a flare was higher for patients who were female, younger, non-White, and Hispanic/Latino; those who had infectious/parasitic disease history; and those with more active GPP. The mean annualized flare rate was 0.91 flares per patient per year; between flares, there was a mean of 5.9 months. There was an increase seen in prescriptions from the preflare period to flare episode, followed by a decrease during the postflare period. There were frequent treatment alterations of off-label biologics and nonsteroidal systemic agents.

"Treatment strategy for GPP flares is not standardized, and the course of medication in periflare time periods was often altered," the authors write. "High discontinuation and switching rates among biologic users suggest the need for more effective long-term GPP treatments."

Several authors disclosed ties to the pharmaceutical industry.

Abstract/Full Text

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

Source: HealthDay

Posted : 2025-04-17 06:00

Read more

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Popular Keywords