Fracture Risk Higher in Women With T2DM Due to Poorer Physical Function

Follow Drugslib on

Medically reviewed by Drugs.com.

By Elana Gotkine HealthDay Reporter

FRIDAY, Aug. 9, 2024 -- Women with type 2 diabetes (T2D) have higher bone mineral density (BMD) and better bone microarchitecture, but poorer physical function than women without diabetes, according to a study published online Aug. 7 in JAMA Network Open.

Michail Zoulakis, M.D., from the Sahlgrenska Osteoporosis Centre at the University of Gothenburg in Sweden, and colleagues conducted a prospective observational study based on the population-based Sahlgrenska University Hospital Prospective Evaluation of Risk of Bone Fractures study cohort of older women to examine whether poorer skeletal characteristics or worse physical function could explain the increased fracture risk seen in T2D. Of 3,008 women aged 75 to 80 years, 294 with T2D were compared to 2,714 without diabetes.

The researchers found that women with T2D had higher BMD at all sites compared with women without. Women with T2D had 7.4 percent greater cortical area and 1.3 percent greater density at the tibia; they also had 8.7 percent higher trabecular bone volume fraction. No difference in the bone material strength index (BMSi) was seen between women with T2D and those without. Lower performance on all physical function tests was seen for women with T2D. Compared with women without diabetes, those with T2D had 9.7 percent lower grip strength, 9.9 percent slower gait speed, and 13.9 percent slower timed up-and-go time. There were 1,071 incident fractures, 853 major osteoporotic fractures, and 232 hip fractures during a median follow-up of 7.3 years. T2D was associated with an increased risk for any fracture and major osteoporotic fractures in adjusted Cox regression models (hazard ratios [95 percent confidence intervals], 1.26 [1.04 to 1.54] and 1.25 [1.00 to 1.56], respectively).

"Older women with T2D have higher BMD, better bone microarchitecture, and no different BMSi, but poorer physical function than women without diabetes," the authors write. "This could be the principal reason for the increased fracture risk observed in this study among older women with T2D."

Several authors disclosed ties to the pharmaceutical industry.

Abstract/Full Text

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

Source: HealthDay

Posted : 2024-08-10 01:15

Read more

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Popular Keywords