Ischemic Strokes Less Severe With Left Atrial Appendage Closure in A-Fib

Medically reviewed by Carmen Pope, BPharm. Last updated on Dec 6, 2023.

By Elana Gotkine HealthDay Reporter

WEDNESDAY, Dec. 6, 2023 -- For patients with atrial fibrillation, ischemic strokes (IS) are less often fatal or disabling with left atrial appendage closure (LAAC) prophylaxis than with direct oral anticoagulant (DOAC) prophylaxis, according to a study published online Nov. 22 in JACC: Clinical Electrophysiology.

Mohit K. Turagam, M.D., from the Icahn School of Medicine at Mount Sinai in New York City, and colleagues conducted a retrospective analysis of consecutive patients undergoing LAAC at eight centers who developed an IS (ISLAAC; 125 patients) compared with 322 contemporaneous patients who developed IS during DOAC treatment (ISDOAC).

The researchers found that at both hospital discharge and three months later, strokes were less frequently disabling/fatal with ISLAAC than ISDOAC (38.3 versus 70.3 percent and 33.3 versus 56.2 percent, respectively). After propensity score matching, differences in stroke severity persisted. In a multivariate regression analysis, independent associations were seen for ISLAAC with fewer disabling/fatal strokes at discharge and three months and with fewer deaths at three months (odds ratios, 0.22, 0.25, and 0.28, respectively).

"Both of these strategies, LAAC and blood thinners, are overall effective in preventing stroke in patients with a-fib, but strokes can infrequently still occur with either prevention strategy," coauthor Vivek Reddy, M.D., also from the Icahn School of Medicine at Mount Sinai, said in a statement. "These data indicate that these breakthrough strokes are considerably worse when they occur while taking blood thinners -- the strokes are more severe and more often fatal -- than after LAAC."

Several authors disclosed ties to the medical technology industry.

Abstract/Full Text (subscription or payment may be required)

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

Source: HealthDay

Read more

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Popular Keywords