Lasting Benefits Seen for Cardiac Resynchronization Therapy With Defibrillator

Follow Drugslib on

Medically reviewed by Carmen Pope, BPharm. Last updated on Jan 18, 2024.

By Elana Gotkine HealthDay Reporter

THURSDAY, Jan. 18, 2024 -- Receipt of a cardiac-resynchronization therapy-defibrillator (CRT-D) offers long term benefit for patients with heart failure, reduced ejection fraction, and a widened QRS complex, according to a study published in the Jan. 18 issue of the New England Journal of Medicine.

John L. Sapp, M.D., from Dalhousie University in Halifax, Nova Scotia, Canada, and colleagues randomly assigned patients with New York Heart Association class II or III heart failure, a left ventricular ejection fraction of 30 percent or less, and an intrinsic QRS duration of 120 msec or more to receive an implantable cardioverter-defibrillator (ICD) alone or a CRT-D. A total of 1,798 patients were enrolled, of whom 1,050 were included in the long-term survival trial (median duration of follow-up, 7.7 years; median duration of follow-up for those who survived, 13.9 years).

The researchers found that death occurred in 76.4 percent of 530 patients assigned to the ICD group and 71.2 percent of the 520 patients assigned to the CRT-D group. Compared with those assigned to receive an ICD, those assigned to receive a CRT-D had longer time to death (acceleration factor, 0.80). A secondary outcome event occurred in 77.7 and 75.4 percent of patients in the ICD and CRT-D groups, respectively.

"This long-term follow-up trial showed a benefit with respect to mortality among patients who received a CRT-D as compared with those who received a standard ICD, and this benefit appears to have been sustained over time," the authors write.

Abstract/Full Text (subscription or payment may be required)

Editorial (subscription or payment may be required)

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

Source: HealthDay

Posted : 2024-01-19 04:15

Read more

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Popular Keywords