Liberal Transfusion Strategy Not Beneficial for Patients With TBI, Anemia
Medically reviewed by Drugs.com.
By Elana Gotkine HealthDay Reporter
MONDAY, July 1, 2024 -- A liberal transfusion strategy does not reduce the risk of unfavorable neurologic outcome at six months among critically ill patients with traumatic brain injury and anemia, according to a study published online June 13 in the New England Journal of Medicine to coincide with the annual Critical Care Reviews Meeting, held from June 12 to 14 in Belfast, Northern Ireland.
Alexis F. Turgeon, M.D., from the Université Laval in Quebec City, and colleagues randomly assigned 742 adults with moderate or severe traumatic brain injury and anemia to receive transfusion of red cells according to a liberal strategy (initiated at a hemoglobin level of ≤10 g/dL) or a restrictive strategy (transfusions initiated at ≤7 g/dL); 371 patients were assigned to each group.
The researchers found that the median hemoglobin level in the intensive care unit was 10.8 and 8.8 g/dL among those assigned to the liberal and restrictive strategies, respectively. An unfavorable neurologic outcome as assessed by the score on the Glasgow Outcome Scale-Extended (GOS-E) at six months occurred in 68.4 and 73.5 percent of patients in the liberal-strategy and restrictive-strategy groups, respectively (adjusted absolute difference, 5.4 percentage points; 95 percent confidence interval, −2.9 to 13.7). A liberal strategy was associated with higher scores on some but not all scales assessing functional independence and quality of life among survivors. Transfusion strategy was not associated with mortality or depression.
"Although several patient-reported outcomes suggest potentially better results with a liberal strategy, firm conclusions may not be drawn," the authors write.
Several authors disclosed ties to the biopharmaceutical industry.
Abstract/Full Text (subscription or payment may be required)
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
Source: HealthDay
Posted : 2024-07-02 01:15
Read more
- How Long Do Newborns Sleep?
- Is There a Relationship Between Complex Trauma and Alcohol Use…
- HLM Editors Shared Our Skin Care Routines with Expert Dermatologists —…
- What Is a Calm-Down Corner?
- Pesticide Exposure Tied to Increased Risk for Stillbirth
- The Health Benefits of Pilates for Older Adults
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Popular Keywords
- metformin obat apa
- alahan panjang
- glimepiride obat apa
- takikardia adalah
- erau ernie
- pradiabetes
- besar88
- atrofi adalah
- kutu anjing
- trakeostomi
- mayzent pi
- enbrel auto injector not working
- enbrel interactions
- lenvima life expectancy
- leqvio pi
- what is lenvima
- lenvima pi
- empagliflozin-linagliptin
- encourage foundation for enbrel
- qulipta drug interactions