Liraglutide Efficacious, Safe for Children Aged 6 to

Follow Drugslib on

Medically reviewed by Carmen Pope, BPharm. Last updated on Sep 12, 2024.

By Elana Gotkine HealthDay Reporter

THURSDAY, Sept. 12, 2024 -- Liraglutide plus lifestyle intervention is efficacious for children aged 6 to <12 years with obesity, according to a study published online Sept. 10 in the New England Journal of Medicine to coincide with the European Association for the Study of Diabetes Congress, held Sept. 9 to 13 in Madrid.

Claudia K. Fox, M.D., from the University of Minnesota Medical School in Minneapolis, and colleagues conducted a phase 3a trial consisting of a 56-week treatment period and a 26-week follow-up period to examine the safety and efficacy of liraglutide in children aged 6 to <12 years. Participants were randomly assigned to receive once-daily subcutaneous liraglutide or placebo (56 and 26, respectively) plus lifestyle interventions.

The researchers found that at week 56, the mean percentage change from baseline in body mass index (BMI) was −5.8 and 1.6 percent with liraglutide and placebo, respectively, representing an estimated difference of −7.4 percentage points. The mean percentage change in body weight was 1.6 and 10.0 percent with liraglutide and placebo, respectively, representing an estimated difference of −8.4 percentage points. A reduction in BMI of at least 5 percent occurred in 46 and 9 percent in the liraglutide and placebo groups, respectively (adjusted odds ratio, 6.3). In the liraglutide and placebo groups, adverse events occurred in 89 and 88 percent; gastrointestinal adverse events occurred in 80 and 54 percent; and serious adverse events were reported in 12 and 8 percent, respectively.

"In this trial, liraglutide was superior to placebo with regard to the percentage change from baseline in BMI and body weight," the authors write.

The study was funded by Novo Nordisk and the authors disclosed ties to the pharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)

Editorial (subscription or payment may be required)

More Information

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

Source: HealthDay

Posted : 2024-09-13 06:00

Read more

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Popular Keywords