Metabolic Surgery May Be Beneficial in MASH-Related Cirrhosis, Obesity

Follow Drugslib on

Medically reviewed by Carmen Pope, BPharm. Last updated on Feb 3, 2025.

By Elana Gotkine HealthDay Reporter

MONDAY, Feb. 3, 2025 -- For patients with compensated metabolic dysfunction-associated steatohepatitis (MASH)-related cirrhosis and obesity, metabolic surgery is associated with a lower risk for incident major adverse liver outcomes (MALO), according to a study published online Jan. 27 in Nature Medicine.

Ali Aminian, M.D., from the Bariatric and Metabolic Institute at the Cleveland Clinic, and colleagues conducted an observational study to compare the effects of metabolic surgery and nonsurgical treatment in patients with obesity and compensated histologically proven MASH-related cirrhosis. The time-to-incident MALO was compared for 62 patients who underwent metabolic surgery and 106 nonsurgical controls who were followed for a mean of 10.0 ± 4.5 years.

The researchers found that the 15-year cumulative incidence of MALO was 20.9 and 46.4 percent in the surgical and nonsurgical groups, respectively, with an adjusted hazard ratio of 0.28. The 15-year cumulative incidence of decompensated cirrhosis was 15.6 and 30.7 percent in the surgical and nonsurgical groups, respectively (adjusted hazard ratio, 0.20).

"In the absence of approved medical therapies for compensated MASH-related cirrhosis, metabolic surgery may represent a safe and effective therapeutic option to influence the trajectory of cirrhosis in selected patients," the authors write.

Several authors disclosed ties to the biopharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

Source: HealthDay

Posted : 2025-02-04 06:00

Read more

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Popular Keywords