Model Can Predict Outcome for Immune Checkpoint Inhibitor Treatment

Follow Drugslib on

Medically reviewed by Drugs.com.

By Elana Gotkine HealthDay Reporter

THURSDAY, Jan. 11, 2024 -- A risk model comprising six inflammatory-related laboratory parameters can predict outcome in patients with metastatic cancer treated with immune checkpoint inhibitors (ICIs), according to a study published online Dec. 4 in BMC Cancer.

Satu Tiainen, from Kuopio University Hospital in Finland, and colleagues obtained laboratory parameters before initiation of ICI treatment in a real-world patient population to establish a practical prognostic risk model for the pretreatment evaluation of response and survival of 158 ICI-treated patients with different types of metastatic cancers. Six inflammation-related parameters (elevated values of neutrophils, platelets, C-reactive protein, erythrocyte sedimentation rate and lactate dehydrogenase, and the presence of anemia) were scored, each with one point. One hundred nine patients with information on all six parameters were stratified into low- and high-risk groups (0 to 3 and 4 to 6 points, respectively).

The researchers found that the risk model was strongly associated with patient outcome. The overall response rate was 30.3 and 53.9 percent in the high- and low-risk groups, respectively. In the high- and low-risk groups, the median overall survival was 10.0 and 27.3 months, and median progression-free survival was 3.9 and 6.3 months, respectively. For both overall and progression-free survival, the risk group remained a significant prognostic factor in Cox multivariate analyses.

"Since the risk model was based on routine blood tests, it is both feasible and inexpensive and thus could easily be incorporated into the clinical practice," the authors write. "Further studies examining larger patient populations are needed to validate the risk model."

Several authors disclosed ties to the pharmaceutical industry.

Abstract/Full Text

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

Source: HealthDay

Posted : 2024-01-12 04:15

Read more

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Popular Keywords