Nirsevimab Effective for Protecting Infants From RSV Lower Respiratory Tract Disease

By Elana Gotkine HealthDay Reporter

Medically reviewed by Carmen Pope, BPharm. Last updated on July 30, 2025.

via HealthDay

WEDNESDAY, July 30, 2025 -- Nirsevimab is effective for protecting infants against respiratory syncytial virus (RSV)-associated lower respiratory tract disease (LRTD), according to a study published online July 22 in Pediatrics.

Amber Hsiao, Ph.D., M.P.H., from the Kaiser Permanente Vaccine Study Center in Oakland, California, and colleagues examined nirsevimab effectiveness against polymerase chain reaction (PCR)-confirmed RSV LRTD and RSV-associated health care utilization during the 2023 to 2024 RSV season at Kaiser Permanente Northern California.

The study included 31,900 infants, 49.1 percent of whom received nirsevimab. The researchers identified 35 and 462 RSV LRTD episodes among nirsevimab-immunized infants and nonimmunized infants (6.10 and 58.51/1,000 person-years, respectively). Nirsevimab effectiveness was 87.2, 98.0, and 71.0 percent against RSV LRTD, hospitalized RSV LRTD, and PCR-confirmed RSV, respectively. Fewer encounters (adjusted means difference, −0.86) and lower odds of hospitalization (odds ratio, 0.11) were seen for nirsevimab-immunized infants with RSV LRTD than nonimmunized infants.

"These findings support the Advisory Committee on Immunization Practice's recommendation for eligible infants aged <8 months entering their first RSV season to receive nirsevimab to reduce the risk of RSV infection," the authors write.

The study was funded by Sanofi, the manufacturer of nirsevimab.

Abstract/Full Text

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

Source: HealthDay

Read more

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Popular Keywords