No Long-Term Cognitive Effects Seen for Menopausal Hormone Therapy

Follow Drugslib on

Medically reviewed by Drugs.com.

By Elana Gotkine HealthDay Reporter

FRIDAY, Nov. 22, 2024 -- Menopausal hormone therapy (mHT) is not associated with long-term cognitive effects versus placebo, according to a study published online Nov. 21 in PLOS Medicine.

Carey E. Gleason, Ph.D., from the University of Wisconsin in Madison, and colleagues examined the long-term effects of mHT initiated in early menopause in participants enrolled in the Kronos Early Estrogen Prevention Study (KEEPS)-Cog trial and its parent study (KEEPS), in which women were randomly assigned to transdermal estradiol, oral conjugated equine estrogens, or placebo during early menopause. The KEEPS Continuation observational longitudinal cohort study involved recontacting KEEPS participants about 10 years after completion of the four-year clinical trial. For 275 participants, cognitive data from both KEEPS and KEEPS Continuation were available.

The researchers observed significant associations between intercepts and slopes for cognitive performance across almost all domains in latent growth models, indicating a change in cognitive factor scores over time. Tests examining the effects of mHT allocation on cognitive slopes were statistically nonsignificant during KEEPS and across all years of follow-up. No long-term cognitive effects of mHT were seen in the KEEPS Continuation study, with baseline cognition and changes during KEEPS being the strongest predictors of later performance. About 10 years after completion of the randomized treatments, participants assigned to mHT in KEEPS performed similarly on cognitive measures to those assigned to placebo.

"The KEEPS Continuation findings extend our understanding of the cognitive effects of mHT beyond short-term effects; specifically, use of hormone therapy within the time frame of early menopause appears to have no long-term cognitive effects," the authors write.

Two authors disclosed ties to the pharmaceutical industry.

Abstract/Full Text

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

Source: HealthDay

Posted : 2024-11-24 00:00

Read more

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Popular Keywords