Novel Biomarker Risk Prediction Models Examined in Chronic Kidney Disease

Follow Drugslib on

By Elana Gotkine HealthDay Reporter

Medically reviewed by Carmen Pope, BPharm. Last updated on Aug 22, 2025.

via HealthDay

FRIDAY, Aug. 22, 2025 -- For adults with nondialysis chronic kidney disease (CKD), risk prediction models incorporating novel biomarkers show comparable discrimination to established risk factors, according to a study published online June 20 in the Journal of the American Society of Nephrology.

Anthony Onoja, Ph.D., from the University of Surrey in the United Kingdom, and colleagues examined novel biomarkers linked to key disease mechanisms to predict the risk for kidney failure, all-cause mortality, or a composite of both in a study including 2,884 adults with nondialysis CKD from 16 U.K. nephrology centers.

The researchers found that a model combining three biomarkers (soluble tumor necrosis factor receptor 1, soluble cluster of differentiation 40, and urinary collagen type 1 α1 chain) showed good discrimination for kidney failure (C-index, 0.86), but a model using established risk factors outperformed this model (C-index, 0.90). A model using three biomarkers (high-sensitivity cardiac troponin T, N-terminal pro-brain natriuretic peptide, and soluble urokinase plasminogen activator receptor) demonstrated equivalent discrimination to an established risk factor model for all-cause mortality (C-index, 0.80 and 0.80, respectively). The biomarker model discrimination was numerically higher than for established risk factors for the composite outcome (C-index, 0.78 versus 0.77); a small but significant improvement in discrimination was seen with the addition of biomarkers to the established risk factors (C-index, 0.80).

"The key finding here is that we can use these biomarkers to understand the underlying mechanisms of disease progression, potentially paving the way to more personalized treatments and medicines for CKD patients," Onoja said in a statement.

Several authors disclosed ties to relevant organizations.

Abstract/Full Text

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

Source: HealthDay

Posted : 2025-08-23 06:00

Read more

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Popular Keywords