🛒 Medication Log Book - Track your medications and health records Shop on Amazon →

PFOS, PFHA, Mono-Iso-Nonyl-Phthalate Can Predict Lung Cancer Mortality

Follow Drugslib on

By Elana Gotkine HealthDay Reporter

Medically reviewed by Carmen Pope, BPharm. Last updated on March 18, 2026.

via HealthDay

WEDNESDAY, March 18, 2026 -- A model composed of perfluorooctanesulfonic acid (PFOS), perfluoroheptanoic acid (PFHA), and the plasticizer mono-iso-nonyl-phthalate can predict lung cancer mortality, according to a study published online March 4 in Clinical Cancer Research.

Ehsan Irajizad, Ph.D., from The University of Texas MD Anderson Cancer Center in Houston, and colleagues screened for 29 known microplastics, forever plastics (perfluoroalkyl and polyfluoroalkyl substances [PFAS]), and plasticizer chemicals in 245 sera collected preceding a lung cancer diagnosis and in 1,200 noncase sera from individuals with a history of smoking.

The researchers observed associations for higher circulating levels of PFOS, PFHA, and mono-iso-nonyl-phthalate with an increased risk for lung cancer death, but not with lung cancer incidence. Individuals with PFAP scores (PFOS + PFHA + mono-iso-nonyl-phthalate) in the highest quantile had a significantly higher risk for death from lung cancer compared with the lowest quantile, with cause-specific and subdistributional hazard ratios of 1.86 and 1.82, respectively. Across strata defined by age, sex, smoking history, histologic subtype, and stage at diagnosis, the PFAP model remained an independent predictor of lung cancer-specific mortality.

"These findings highlight the potential for personalized blood-based assessment of PFAS and plasticizers exposure and determinants of lung cancer mortality outcomes," the authors write.

Abstract/Full Text (subscription or payment may be required)

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

Source: HealthDay

Recommended Health Products
Pulse Oximeter
Respiratory Care Pulse Oximeter Monitor blood oxygen levels instantly View on Amazon →
Digital Thermometer
Health Monitoring Digital Thermometer Fast and accurate temperature reading View on Amazon →
As an Amazon Associate we earn from qualifying purchases.

Posted : 2026-03-19 01:54

Read more

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Popular Keywords