Preclinical Blood Test IDs Risk for Respiratory Death, Incident COPD

Medically reviewed by Carmen Pope, BPharm. Last updated on Sep 11, 2024.

By Elana Gotkine HealthDay Reporter

WEDNESDAY, Sept. 11, 2024 -- A proteomic signature indicating increased respiratory susceptibility identifies the risk for respiratory death, incident chronic obstructive pulmonary disease (COPD), and respiratory exacerbations, according to a study published online Sept. 10 in the American Journal of Respiratory and Critical Care Medicine.

Gabrielle Y. Liu, M.D., from the UC Davis School of Medicine in Sacramento, California, and colleagues examined whether a proteomic risk score trained on accelerated decline in lung function can predict the risk for future respiratory disease and mortality in CARDIA, a population-based cohort starting in young adulthood. To identify accelerated and normal decline trajectories, longitudinal measurement of forced expiratory volume in 1 second percent predicted was used. Protein aptamers associated with an accelerated decline trajectory were identified. The proteomic respiratory susceptibility score was derived based on these circulating proteins and applied to the U.K. Biobank and COPDGene.

The researchers found an independent association for a higher susceptibility score with all-cause mortality (hazard ratios [HR], 1.56 and 1.75 in the U.K. Biobank and COPDGene); respiratory mortality (HR, 2.39 and 1.81 in the U.K. Biobank and COPDGene); incident COPD (HR, 1.84 in the U.K. Biobank); incident respiratory exacerbation (odds ratio [OR], 1.10 in COPDGene); and incident exacerbation requiring hospitalization (OR, 1.17 in COPDGene).

"The proteins identified in this study show promise as biomarkers for impaired respiratory health. Further study to elucidate their utility as modifiable targets for the prevention and interception of chronic lung disease in at-risk populations is warranted," the authors write.

The COPDGene study is funded by contributions from several pharmaceutical companies.

Abstract/Full Text (subscription or payment may be required)

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

Source: HealthDay

Read more

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Popular Keywords