Rebound Weight Gain Common After Discontinuing Antiobesity Medications
By Elana Gotkine HealthDay Reporter

FRIDAY, July 25, 2025 -- Antiobesity medications (AOMs) yield weight loss during use, followed by weight regain after discontinuation of treatment, according to a review published online July 21 in BMC Medicine.
Han Wu, from the Peking University People's Hospital in Beijing, and colleagues conducted a systematic review to explore the long-term effects of AOMs on body weight. The review included randomized controlled trials of AOMs conducted within populations for at least four weeks and followed for four or more weeks after discontinuation. Weight change was reported during drug treatment and after drug discontinuation.
The researchers found that compared with the control group, AOM treatment had weight loss effects at week 4 after discontinuation (weighted mean difference, −0.32 kg; 95 percent confidence interval, −3.60 to 2.7; P = 0.85). Compared with the control group, AOMs were associated with significant weight regain at eight weeks after drug discontinuation (weighted mean difference, 1.50 kg; 95 percent confidence interval, 1.32 to 1.68; P < 0.0001), a trend that continued through 12 and 20 weeks. Significant weight regain after 12 weeks of drug discontinuation was only seen in studies with glucagon-like peptide 1 receptor agonist-related drugs. Significant weight gain after drug discontinuation was seen in studies in which weight loss was greater during treatment than in the control group and in studies in which lifestyle interventions were continued.
"According to the trajectory of weight regain, body weight continued to decrease within four weeks after treatment discontinuation and then started to show a gradually increasing trend after eight weeks," the authors write.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
Source: HealthDay
Posted : 2025-07-26 06:00
Read more

- Genentech Provides Update on Astegolimab in Chronic Obstructive Pulmonary Disease
- U.S. Hospitals Face Shortages in Essential Staff Due to Foreign Residency Visa Delays
- Moderna Receives Full U.S. FDA Approval for COVID-19 Vaccine, Spikevax in Children Aged 6 Months Through 11 Years at Increased Risk for COVID-19 Disease
- Digital Model Based on Noninvasive Factors Shows Accuracy for Identifying IBD in Children
- Nocturnal Hypertension Control Improved With Bedtime Antihypertensive Dosing
- Liraglutide May Reduce Migraine Burden in Adults With Obesity, Migraine
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Popular Keywords
- metformin obat apa
- alahan panjang
- glimepiride obat apa
- takikardia adalah
- erau ernie
- pradiabetes
- besar88
- atrofi adalah
- kutu anjing
- trakeostomi
- mayzent pi
- enbrel auto injector not working
- enbrel interactions
- lenvima life expectancy
- leqvio pi
- what is lenvima
- lenvima pi
- empagliflozin-linagliptin
- encourage foundation for enbrel
- qulipta drug interactions