Review Compares Drug Interventions for Acute Migraine Treatment
Medically reviewed by Drugs.com.
By Elana Gotkine HealthDay Reporter
MONDAY, Sept. 23, 2024 -- All active interventions show superior efficacy to placebo for freedom from pain, and most do for sustained pain freedom, for the acute treatment of migraine among adults, according to a review published online Sept. 18 in The BMJ.
William K. Karlsson, from the Danish Headache Centre at Copenhagen University Hospital-Rigshospitalet, and colleagues conducted a systematic review and network meta-analysis to compare all licensed drug interventions as oral monotherapy for acute treatment of migraine episodes in adults. Data were included from 137 randomized controlled trials involving 89,445 participants allocated to one of 17 active interventions or placebo.
The researchers found that compared with placebo, all active interventions showed superior efficacy for pain freedom at two hours (odds ratios from 1.73 for naratriptan to 5.19 for eletriptan), and most also showed superior efficacy for sustained pain freedom to 24 hours (odds ratios from 1.71 for celecoxib to 7.58 for ibuprofen). Eletriptan was the most effective drug for pain freedom at two hours in head-to-head comparisons (odds ratios from 1.46 to 3.01), followed by rizatriptan, sumatriptan, and zolmitriptan (odds ratios, 1.59 to 2.44, 1.35 to 2.04, and 1.47 to 1.96, respectively). The most efficacious interventions for sustained pain freedom were eletriptan and ibuprofen (odds ratios from 1.41 to 4.82).
"The results of this systematic review and network meta-analysis offer the best available evidence to guide the choice of acute oral drug interventions for migraine episodes," the authors write. "Our results are in line with recent observational evidence."
Several authors disclosed ties to the biopharmaceutical industry.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
Source: HealthDay
Posted : 2024-09-24 12:00
Read more
- Rates of Anxiety, Depression Rising Among Americans, Especially the Young
- NIH Trial of Rectal Microbicide for HIV Prevention Begins in the United States
- Skin Patch Uses 'Imperceptible' Electric Zaps to Heal Wounds Without Drugs
- Supply Chain Issues Less Likely to Yield Drug Shortages in Canada Versus U.S.
- ASN: Atrasentan Significantly and Clinically Meaningfully Cuts Proteinuria
- COVID-19 Pandemic-Linked Increase in Alcohol Use Persisting
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Popular Keywords
- metformin obat apa
- alahan panjang
- glimepiride obat apa
- takikardia adalah
- erau ernie
- pradiabetes
- besar88
- atrofi adalah
- kutu anjing
- trakeostomi
- mayzent pi
- enbrel auto injector not working
- enbrel interactions
- lenvima life expectancy
- leqvio pi
- what is lenvima
- lenvima pi
- empagliflozin-linagliptin
- encourage foundation for enbrel
- qulipta drug interactions