Review: Cytisine Effective for Smoking Cessation Versus Placebo

Follow Drugslib on

Medically reviewed by Carmen Pope, BPharm. Last updated on Jan 2, 2024.

By Elana Gotkine HealthDay Reporter

TUESDAY, Jan. 2, 2024 -- Cytisine increases the chances of successful smoking cessation compared with placebo, according to a review published online Dec. 31 in Addiction.

Omar De Santi, from the Hospital Nacional Profesor Alejandro Posadas in Buenos Aires, Argentina, and colleagues reviewed the efficacy and safety of cytisine for smoking cessation. Twelve randomized controlled trials (RCTs) conducted in health centers of any level and involving smokers of any age or gender were included.

The researchers found that eight RCTs (with 5,922 patients) compared cytisine to placebo at the standard dose; the risk ratio was 2.25 for the 2,996 who took cytisine. There was a direct association for greater intensity of behavioral therapy with the efficacy findings (moderate-quality evidence). In trials conducted in low- and middle-income countries, the confirmed efficacy of cytisine was not evidenced. The number needed to treat was estimated at 11. The efficacy of cytisine was compared to nicotine replacement therapy in two trials; modest results in favor of cytisine were yielded by the combination of both studies. No clear benefit was seen for cytisine in three trials comparing cytisine with varenicline. The risk ratio was 1.24 on meta-analyses of all nonserious adverse events in the cytisine group versus placebo groups.

"More investigations regarding cytisine should fully consider assessing the cost-effectiveness and economic evaluations of community-based tobacco dependence interventions," the authors write.

Abstract/Full Text (subscription or payment may be required)

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

Source: HealthDay

Posted : 2024-01-03 02:15

Read more

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Popular Keywords