Risk for Death, MACE Increased for Patients With Adult-Onset Type 1 Diabetes

Medically reviewed by Carmen Pope, BPharm. Last updated on May 16, 2025.

By Elana Gotkine HealthDay Reporter

FRIDAY, May 16, 2025 -- Adult-onset type 1 diabetes (T1D) is associated with an increased risk for death and major adverse cardiovascular events (MACE), according to a study published online May 14 in the European Heart Journal.

Yuxia Wei, from the Karolinska Institutet in Stockholm, and colleagues examined mortality, MACE, and prognostic factors in adult-onset T1D, especially among those diagnosed at age 40 years or older. Data were included for individuals with adult-onset T1D (10,184 participants) or type 2 diabetes (T2D; 375,523) in 2001 to 2020 and 509,172 population controls.

The researchers found that compared with population controls, people with T1D had a higher incidence of MACE (hazard ratio, 1.30), all-cause mortality (hazard ratio, 1.71), and mortality from cardiovascular or noncardiovascular disease, cancer, or infection. Compared with those with T2D, they had lower MACE incidence (hazard ratio, 0.67) and higher mortality from diabetic coma or ketoacidosis (hazard ratio, 7.04). Most deaths were accounted for by smoking (population attributable risk fraction, 10.7 percent) and glycated hemoglobin (HbA1c) ≥53 mmol/mol (10.4 percent), while most MACE events in T1D were accounted for by overweight/obesity, smoking, and high HbA1c (19.8, 8.4, and 8.8 percent, respectively). Similar results were seen for those diagnosed with T1D at age 40 years or older, although lower insulin pump use and higher HbA1c were seen when compared with those diagnosed earlier.

“We show that the prognosis can be significantly improved by preventing smoking and obesity and improving glucose control, not least in people diagnosed at older ages,” senior study author Sofia Carlsson, Ph.D., also from the Karolinska Institutet, said in a press release. “We hope to shed light on these issues in the coming years."

One author disclosed ties to the biopharmaceutical industry.

Abstract/Full Text

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

Source: HealthDay

Read more

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Popular Keywords