Roux-en-Y Gastric Bypass, Sleeve Gastrectomy Beat Adjustable Gastric Banding for Severe Obesity

Follow Drugslib on

Medically reviewed by Carmen Pope, BPharm. Last updated on April 10, 2025.

By Elana Gotkine HealthDay Reporter

THURSDAY, April 10, 2025 -- For adults with severe obesity, Roux-en-Y gastric bypass and sleeve gastrectomy are more effective than adjustable gastric banding, according to a study published online March 31 in The Lancet Diabetes & Endocrinology.

Sanjay Agrawal, M.B.B.S., from Homerton University Hospital in London, and colleagues conducted a pragmatic, randomized controlled trial in 12 U.K. hospitals involving adults meeting national criteria for metabolic and bariatric surgery. Initially, the trial included two arms: Roux-en-Y gastric bypass and adjustable gastric banding, and sleeve gastrectomy was added at 2.6 years after initiation when it became widely available in the United Kingdom.

The analyses included 1,346 participants: 34, 34, and 31 percent in the Roux-en-Y gastric bypass group, adjustable gastric banding group, and sleeve gastrectomy group, respectively. The researchers found that 68, 25, and 41 percent of participants in the Roux-en-Y gastric bypass, adjustable gastric banding, and sleeve gastrectomy groups, respectively, achieved at least 50 percent excess weight loss. The mean EuroQol 5-Dimension utility quality-of-life scores were 0.72 for Roux-en-Y gastric bypass, 0.62 for adjustable gastric banding, and 0.68 for sleeve gastrectomy. Following surgery, there were 1,651 adverse events (6.0, 4.6, and 5.7 per year after Roux-en-Y gastric bypass, adjustable gastric banding, and sleeve gastrectomy, respectively). From random assignment to three years, there were 11 deaths: one attributable to surgery in the adjustable gastric banding group and 10 not attributable to surgery. The most cost-effective approach was Roux-en-Y gastric bypass.

"Future research to understand longer-term outcomes and to compare metabolic and bariatric surgery with obesity management medications is needed to guide evidence-based practice in this rapidly evolving field," the authors write.

Several authors disclosed ties to relevant organizations.

Abstract/Full Text

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

Source: HealthDay

Posted : 2025-04-11 06:00

Read more

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Popular Keywords