Study Quantifies Breast Shrinkage After T1 Tumor Lumpectomy

Follow Drugslib on

Medically reviewed by Carmen Pope, BPharm. Last updated on April 4, 2025.

By Elana Gotkine HealthDay Reporter

FRIDAY, April 4, 2025 -- Patients with T1 tumors undergoing breast-conserving therapy/radiation therapy (BCT/RT) may lose about 20 percent of breast volume at one year, according to a study published in the April issue of Plastic and Reconstructive Surgery.

Miriam Becker, from the University of California in San Diego, and colleagues calculated breast volume changes for 113 patients (115 breasts) after T1 tumor lumpectomies. Volumes were calculated from mammograms from preoperative baseline to seven years after radiation. Changes over time were assessed, with subset analyses of tumor volume of the breast of 10 percent or less and greater than 10 percent (67 and 48 patients, respectively).

During surgery, patients lost 8.3 percent of breast volume. The researchers found that volume loss was 19.3 percent at one year after BCT/RT. Total volume loss was 26.6 percent by year 5. In addition to lumpectomy defects, five-year volume loss was 21.7 and 29.5 percent for tumor/breast volume greater than 10 percent or 10 percent or less, respectively. No significant difference was seen for volume loss between subgroups. Larger breast volume was a significant predictor of greater volume loss for all five years, followed by diabetes and smoking history.

"Larger breast size, diabetes, and smoking history may predict increased volume loss whether whole- or partial-breast radiation was administered, and treatment with cytotoxic chemotherapy may predict increased shrinkage in patients receiving whole-breast radiation," the authors write.

Abstract/Full Text

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

Source: HealthDay

Posted : 2025-04-05 06:00

Read more

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Popular Keywords