Subclinical Cardiac Dysfunction Linked to Markers of Neurodegeneration

Follow Drugslib on

Medically reviewed by Carmen Pope, BPharm. Last updated on April 1, 2025.

By Elana Gotkine HealthDay Reporter

TUESDAY, April 1, 2025 -- Subclinical cardiac dysfunction is associated with brain imaging markers of neurodegeneration, according to a study published online March 26 in Neurology.

Amber Yaqub, from Erasmus MC in Rotterdam, the Netherlands, and colleagues leveraged data from seven prospective, community-based cohorts across Europe and the United States to examine associations between cardiac function, clinical heart failure, and structural markers on brain magnetic resonance imaging. Data were included for 10,889 participants (mean age, 66.8 years).

The researchers found a consistent association for markers of systolic dysfunction with smaller total brain volume (TBV; e.g., adjusted standardized mean difference for moderate-to-severe dysfunction, −0.19). Associations were also seen for impaired relaxation and restrictive diastolic dysfunction with smaller TBV (e.g., for impaired relaxation, −0.08) and hippocampal volume (−0.18); results were similar for E/A-ratio. No consistent association was seen for systolic and diastolic dysfunction with volume of white matter hyperintensities. Overall, 3.4 percent of participants from five cohorts with available data had clinical heart failure, which was associated with smaller brain volume, especially in the hippocampus (−0.13).

"These results highlight the importance of preserving cardiac function for promoting brain health during aging and encourage further investigations into the complex interplay between cardiac and brain health," the authors write.

Abstract/Full Text

Editorial (subscription or payment may be required)

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

Source: HealthDay

Posted : 2025-04-02 06:00

Read more

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Popular Keywords