Topical Testosterone + Exercise No Aid for Hip Fracture Recovery in Women

Follow Drugslib on

Medically reviewed by Carmen Pope, BPharm. Last updated on May 20, 2025.

By Lori Solomon HealthDay Reporter

TUESDAY, May 20, 2025 -- Topical testosterone therapy does not significantly improve functional outcomes beyond supervised exercise training in older women recovering from a hip fracture, according to a study published online May 15 in JAMA Network Open.

Ellen F. Binder, M.D., from the Washington University School of Medicine in St. Louis, and colleagues evaluated the effects of a supervised exercise program combined with topical testosterone therapy on functional outcomes in women aged 65 years or older with a recent hip fracture. The analysis included 122 women randomly assigned to exercise plus testosterone, exercise plus placebo, or enhanced usual care.

The researchers found no significant differences in the mean change in the six-minute walking distance between baseline and 24 weeks for exercise plus topical testosterone gel (53 patients; 42.7 m) versus exercise plus placebo gel (51 patients; 40.5 m) or enhanced usual care (18 patients; 37.7 m).

"It is notable that at the end of the intervention period, women assigned to exercise and testosterone had a significant reduction in the use of walking aids and greater improvement in a short-distance performance measure than women assigned to exercise and placebo," Binder said in a statement. "This finding will need further exploration to confirm whether testosterone therapy can facilitate recovery after a hip fracture in older women."

Several authors disclosed ties to the pharmaceutical and medical technology industries.

Abstract/Full Text

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

Source: HealthDay

Posted : 2025-05-21 06:00

Read more

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Popular Keywords