Ultraprocessed Food Consumption Linked to Nonmotor Prodromal Parkinson Disease

Follow Drugslib on

Medically reviewed by Carmen Pope, BPharm. Last updated on May 8, 2025.

By Elana Gotkine HealthDay Reporter

WEDNESDAY, May 7, 2025 -- Long-term consumption of ultraprocessed foods (UPF) is associated with nonmotor prodromal Parkinson disease (PD) features, according to a study published online May 7 in Neurology.

Peilu Wang, M.D., Ph.D., from the Institute of Nutrition at Fudan University in Shanghai, and colleagues examined the association between long-term UPF consumption and nonmotor features suggestive of prodromal PD in a longitudinal analysis of participants from the Nurses' Health Study and Health Professionals Follow-Up Study. Repeated food frequency questionnaires (1984 to 2006) were used to assess UPF consumption.

The study analyses included 42,853 participants. The researchers found that the multivariable-adjusted odds ratios for having three or more versus zero prodromal features were 2.47 and 1.50 for cumulative intake and baseline intake, respectively, comparing extreme quintiles of UPF consumption. For combinations of all features except constipation and for combinations of three features, similar results were observed (odds ratios, 2.00 and 2.47, respectively). Higher UPF consumption was also associated with elevated odds of individual prodromal features, including probable rapid eye movement sleep behavior disorder, constipation, body pain, and depressive symptoms.

"Future prospective studies are required to confirm whether reducing UPF consumption can slow the progression from prodromal PD to overt PD," the authors write. "Overall, our study adds to the growing body of evidence to support the adverse effects of UPF consumption on neurodegenerative diseases."

Abstract/Full Text (subscription or payment may be required)

Editorial (subscription or payment may be required)

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

Source: HealthDay

Posted : 2025-05-08 12:00

Read more

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Popular Keywords