Aristada

Generic name: Aripiprazole Lauroxil (injection)
Brand names: Aristada
Drug class: Atypical antipsychotics

Usage of Aristada

Aristada (aripiprazole) is used in adults to treat the symptoms of schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions).

Aristada Initio is used together with oral aripiprazole to start or restart Aristada.

Aristada belongs to a class of medications called atypical antipsychotics. Aripiprazole works by changing the activity of certain natural substances in the brain.

Aristada side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

High doses or long-term use of Aristada can cause a serious movement disorder that may not be reversible. The longer you use this medicine, the more likely you are to develop this disorder, especially if you are a woman or an older adult.

You may have increased sexual urges, unusual urges to gamble, or other intense urges while using this medicine. Talk with your doctor if this occurs.

Aristada may cause serious side effects. Call your doctor at once if you have:

  • uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);
  • feeling unusually hot or cold;
  • trouble swallowing;
  • a seizure;
  • feeling like you might pass out (even while lying down);
  • severe nervous system reaction - very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out;
  • low blood cell counts - fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath;
  • signs of infection - fever, chills, sore throat, body aches, unusual tiredness, loss of appetite, bruising or bleeding; or
  • high blood sugar - increased thirst, increased urination, dry mouth, fruity breath odor.

    • Common Aristada side effects may include:

  • feeling restless;
  • pain where the medicine was injected;
  • weight gain; or
  • drowsiness.

    • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Aristada

    You should not be treated with Aristada if you are allergic to aripiprazole.

    Tell your doctor if you have never taken Aristada.

    Aripiprazole may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use.

    To make sure this medicine is safe for you, tell your doctor if you have ever had:

  • a problem in receiving an injection in the arm or buttocks;
  • heart disease, a heart attack or stroke;
  • high or low blood pressure;
  • high blood sugar, diabetes (in you or family member);
  • a seizure;
  • high cholesterol or triglycerides;
  • dehydration; or
  • low white blood cell (WBC) counts.

    • Using antipsychotic medicine in the last 3 months of pregnancy may cause serious problems in the newborn. Tell your doctor right away if you get pregnant. Do not stop the medicine without your doctor's advice.

    If you are pregnant, your name may be listed on a pregnancy registry to track the effects of aripiprazole on the baby.

    Ask a doctor if it is safe to breastfeed while using this medicine.

    Relate drugs

    How to use Aristada

    Usual Adult Dose for Schizophrenia:

    Aripiprazole Lauroxil Extended-Release IM Suspension: -Initial dose: -Patients stable on oral aripiprazole IR 10 mg/day: 441 mg IM via deltoid or gluteal injection ONCE PLUS aripiprazole lauroxil 675 mg IM ONCE OR aripiprazole IR 10 mg orally once a day for 21 days -Patients stable on oral aripiprazole IR 15 mg/day: Initial dose 662 mg IM via gluteal injection ONCE PLUS aripiprazole lauroxil 675 mg IM ONCE OR aripiprazole IR 15 mg orally once a day for 21 days -Patients stable on oral aripiprazole IR at least 20 mg/day: 882 mg IM via gluteal injection ONCE PLUS aripiprazole lauroxil 675 mg IM ONCE OR aripiprazole IR once a day for 21 days. -Maintenance doses: 441 mg, 662 mg, or 882 mg IM monthly, 882 mg IM every 4 to 6 weeks, or 1064 mg IM every 2 months; this drug should not be given sooner than 14 days after the previous injection. Re-initiation of treatment: Aristada Initio 675 mg IM ONCE plus 30 mg of aripiprazole IR orally ONCE Comments: Prior to initiating therapy with extended-release IM formulations, tolerability should be established with oral formulations; it may take up to 2 weeks to fully assess tolerability due to the half-life of aripiprazole. -The first dose of the extended-release IM formulation should be given on the same day as the initiation/re-initiation dose; providers should avoid injecting both formulations in the same deltoid or gluteal muscle. -Dose regimen adjustments (including addition of oral supplementation) will be needed for missed doses.

    Warnings

    Aristada is not approved for use in older adults with psychotic conditions related to dementia. Aripiprazole may increase the risk of death in older adults with dementia-related psychosis.

    What other drugs will affect Aristada

    Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

    Tell your doctor about all your current medicines. Many drugs can affect aripiprazole, especially:

  • blood pressure medications;
  • a benzodiazepine sedative like Valium, Klonopin, or Xanax;
  • bronchodilator asthma medication;
  • cold or allergy medicine (Benadryl and others);
  • medicine to treat overactive bladder;
  • medicine to treat Parkinson's disease; or
  • medicine to treat stomach problems, motion sickness, or irritable bowel syndrome.

    • This list is not complete and many other drugs may interact with aripiprazole. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

    Popular FAQ

    If you miss a dose of Aristada, contact your healthcare provider right away to reschedule your missed injection. Depending upon how long it has been since your last dose, you may need to have extra medicine at your next injection, using Aristada Initio, oral aripiprazole or both. You should not miss any doses.

    Aristada Initio (aripiprazole lauroxil 650 mg) is used as a long-acting, single intramuscular (IM) injection, with a single oral dose of aripiprazole, for adult patients starting or re-initiating treatment with Aristada to treat schizophrenia. Aristada Initio is not for repeat dosing. Aristada is the long-acting maintenance treatment form of aripiprazole lauroxil given by IM injection. Aristada is administered monthly, every 6 weeks, or every 8 weeks, depending on dose (441 mg, 662 mg, 882 mg or 1064 mg). The first Aristada injection may be administered on the same day as Aristada Initio or up to 10 days later. Aristada Initio is not interchangeable with Aristada due to differences in how these drugs act in the body.

    Yes, the manufacturer Alkermes offers a copay card for eligible patients with commercial insurance. Your co-pay may be as low as $10 per prescription. They may have other forms of financial Aristada patient assistance programs for those without commercial insurance. Call Aristada Care Support at 1-866-ARISTADA or 1-866-274-7823 (9:00 AM-8:00 PM EST, Monday-Friday) or access the Aristada patient assistance application online to learn more.

    Aristada (aripiprazole lauroxil) 441 mg, Aristada 662 mg or Aristada 882 mg are the extended-release strengths used for once monthly dosing of Aristada. The 882 mg dose can also be given every 6 weeks, and the Aristada 1064 mg dose is administered every 2 months. You and your doctor will determine the best dosing option for you. You may also receive one injection of Aristada Initio 675 mg and one oral dose of aripiprazole at the beginning of your treatment. Alternatively, you may be given 21 consecutive days of oral aripiprazole in conjunction with your first Aristada injection. Aristada is used to treat schizophrenia in adults. It is only given as an intramuscular (IM) injection by a healthcare professional.

    Aristada is not a hemostatic agent it is an atypical antipsychotic that works on dopamine, serotonin, and other receptors to help treat schizophrenia, but there is a product called Arista AH Absorbable Hemostat which is a hemostatic agent that may be used in some surgical procedures to help control bleeding.

    Aripiprazole is one of those medications that can cause sleepiness in some people and insomnia (an inability to get to sleep) in others. Aripiprazole should be preferably taken in the morning, especially if it keeps you awake at night. Research also suggests taking it at night may antagonize D2 dopamine receptors and disrupt 24h rhythms in insulin release, possibly exacerbating metabolic dysfunction. Continue reading

    Patients who receive monthly intramuscular injections of Abilify Maintena 400 mg, and have reached steady state concentrations of the drug, can be switched to Aristada 882 mg injection four weeks after their last Abilify Maintena injection. Continue reading

    Aristada (aripiprazole lauroxil) is given as an intramuscular (IM) injection into the muscle of your upper arm or buttock based on the dose your doctor prescribes. Your healthcare provider will give you this injection either once every month, once every six weeks, or once every 2 months depending upon your dose. Continue reading

    Although Abilify (aripiprazole) has been found to cause less weight gain than other atypical antipsychotics, there is evidence that in certain people it can cause significant weight gain and it may be more likely to cause weight gain in people who are taking it for depression alongside other antidepressants. Side effects such as weight gain may be significant enough for some people to discontinue Abilify, even when it is working well to manage symptoms. Continue reading

    If you miss a dose of Aristada, contact your healthcare provider right away to reschedule your missed injection. Depending upon how long it has been since your last dose, you may need to have extra medicine at your next injection, using Aristada Initio, oral aripiprazole or both. You should not miss any doses.

    Aristada Initio (aripiprazole lauroxil 650 mg) is used as a long-acting, single intramuscular (IM) injection, with a single oral dose of aripiprazole, for adult patients starting or re-initiating treatment with Aristada to treat schizophrenia. Aristada Initio is not for repeat dosing. Aristada is the long-acting maintenance treatment form of aripiprazole lauroxil given by IM injection. Aristada is administered monthly, every 6 weeks, or every 8 weeks, depending on dose (441 mg, 662 mg, 882 mg or 1064 mg). The first Aristada injection may be administered on the same day as Aristada Initio or up to 10 days later. Aristada Initio is not interchangeable with Aristada due to differences in how these drugs act in the body.

    Yes, the manufacturer Alkermes offers a copay card for eligible patients with commercial insurance. Your co-pay may be as low as $10 per prescription. They may have other forms of financial Aristada patient assistance programs for those without commercial insurance. Call Aristada Care Support at 1-866-ARISTADA or 1-866-274-7823 (9:00 AM-8:00 PM EST, Monday-Friday) or access the Aristada patient assistance application online to learn more.

    Aristada (aripiprazole lauroxil) 441 mg, Aristada 662 mg or Aristada 882 mg are the extended-release strengths used for once monthly dosing of Aristada. The 882 mg dose can also be given every 6 weeks, and the Aristada 1064 mg dose is administered every 2 months. You and your doctor will determine the best dosing option for you. You may also receive one injection of Aristada Initio 675 mg and one oral dose of aripiprazole at the beginning of your treatment. Alternatively, you may be given 21 consecutive days of oral aripiprazole in conjunction with your first Aristada injection. Aristada is used to treat schizophrenia in adults. It is only given as an intramuscular (IM) injection by a healthcare professional.

    Aristada is not a hemostatic agent it is an atypical antipsychotic that works on dopamine, serotonin, and other receptors to help treat schizophrenia, but there is a product called Arista AH Absorbable Hemostat which is a hemostatic agent that may be used in some surgical procedures to help control bleeding.

    Aripiprazole is one of those medications that can cause sleepiness in some people and insomnia (an inability to get to sleep) in others. Aripiprazole should be preferably taken in the morning, especially if it keeps you awake at night. Research also suggests taking it at night may antagonize D2 dopamine receptors and disrupt 24h rhythms in insulin release, possibly exacerbating metabolic dysfunction. Continue reading

    Patients who receive monthly intramuscular injections of Abilify Maintena 400 mg, and have reached steady state concentrations of the drug, can be switched to Aristada 882 mg injection four weeks after their last Abilify Maintena injection. Continue reading

    Aristada (aripiprazole lauroxil) is given as an intramuscular (IM) injection into the muscle of your upper arm or buttock based on the dose your doctor prescribes. Your healthcare provider will give you this injection either once every month, once every six weeks, or once every 2 months depending upon your dose. Continue reading

    Although Abilify (aripiprazole) has been found to cause less weight gain than other atypical antipsychotics, there is evidence that in certain people it can cause significant weight gain and it may be more likely to cause weight gain in people who are taking it for depression alongside other antidepressants. Side effects such as weight gain may be significant enough for some people to discontinue Abilify, even when it is working well to manage symptoms. Continue reading

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