Brexpiprazole
Generic name: Brexpiprazole
Brand names: Rexulti
Dosage form: oral tablet (0.25 mg; 0.5 mg; 1 mg; 2 mg; 3 mg; 4 mg)
Drug class:
Atypical antipsychotics
Usage of Brexpiprazole
Brexpiprazole is an antipsychotic medication that is used to treat the symptoms of schizophrenia. It is also used together with other medications to treat major depressive disorder in adults.
Brexpiprazole may also be used for purposes not listed in this medication guide.
Brexpiprazole side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
High doses or long-term use of brexpiprazole can cause a serious movement disorder that may not be reversible. The longer you use brexpiprazole, the more likely you are to develop this disorder, especially if you are a diabetic or an older adult.
Brexpiprazole may cause serious side effects. Call your doctor at once if you have:
You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking brexpiprazole. Talk with your doctor if this occurs.
Common side effects of brexpiprazole may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Brexpiprazole
Brexpiprazole may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use.
You should not use brexpiprazole if you are allergic to it.
Tell your doctor if you have ever had:
Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.
Taking antipsychotic medicine in the last 3 months of pregnancy may cause breathing problems, feeding problems, or withdrawal symptoms in the newborn. If you get pregnant, tell your doctor right away. Do not stop taking brexpiprazole without your doctor's advice.
If you are pregnant, your name may be listed on a pregnancy registry to track the effects of brexpiprazole on the baby.
It may not be safe to breastfeed while using brexpiprazole. Ask your doctor about any risk.
Brexpiprazole is not approved for use by anyone younger than 18 years old.
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How to use Brexpiprazole
Usual Adult Dose for Schizophrenia:
Initial dose: 1 mg orally once a day on Days 1 through 4Titration: Based on clinical response and tolerability, titrate to 2 mg once a day on Day 5 through Day 7, then to 4 mg once a day on Day 8Target Dose: 2 to 4 mg orally once a dayMaximum dose: 4 mg/dayUse: Treatment of schizophrenia
Usual Adult Dose for Depression:
Initial dose: 0.5 mg or 1 mg orally once a dayTitration: Based on clinical response and tolerability, dose increases should be done at weekly intervals; titrate to 1 mg once a day, then up 2 mg once a day.Target dose: 2 mg orally once a dayMaximum dose: 3 mg/dayUse: Adjunctive treatment of major depressive disorder (MDD)
Usual Pediatric Dose for Schizophrenia:
Initial dose: 0.5 mg orally once a day on Days 1 through 4Titration: Based on clinical response and tolerability, titrate to 1 mg once a day on Day 5 through Day 7, then to 2 mg once a day on Day 8. Weekly dose increases can be made in 1 mg increments.Target Dose: 2 to 4 mg orally once a dayMaximum dose: 4 mg/dayUse: Treatment of schizophrenia in children 13 to 17 years of age
Warnings
Brexpiprazole is not approved for use in older adults with dementia-related psychosis.
Some young people have thoughts about suicide when first taking this medicine. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.
Brexpiprazole is not approved for use by anyone younger than 18 years old.
What other drugs will affect Brexpiprazole
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Other drugs may affect brexpiprazole, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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