Cablivi

Generic name: Caplacizumab
Drug class: Platelet aggregation inhibitors

Usage of Cablivi

Cablivi is used to treat acquired thrombotic thrombocytopenic purpura (aTTP) in adults. This medicine is given together with immunosuppressant medication and plasma exchange (transfusion).

Cablivi may also be used for purposes not listed in this medication guide.

Cablivi side effects

Get emergency medical help if you have signs of an allergic Reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Cablivi may cause serious side effects. Call your doctor at once if you have:

easy bruising or bleeding (nosebleeds, bleeding gums);

unusual vaginal bleeding;

any bleeding that will not stop; or

signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.

Common side effects of Cablivi may include:

nosebleeds, bleeding gums; or

headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Cablivi

You should not use Cablivi if you are allergic to it.

Tell your doctor if you have ever HAD a bleeding or blood clotting disorder such as hemophilia.

Follow your doctor's instructions about using Cablivi if you are pregnant. Cablivi may increase the risk of bleeding in both mother and baby. However, the benefit of treating aTTP in the mother during pregnancy may outweigh those risks. Tell your doctor right away if you become pregnant.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

Relate drugs

How to use Cablivi

Cablivi is injected under the skin, or given as an infusion into a vein. A healthcare provider will give your first dose and may teach you how to properly use the medication by yourself.

Cablivi and plasma exchange are usually started on the SAMe day. This medicine is then continued for 30 days or longer after your last daily plasma exchange.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you don't understand all instructions.

Cablivi must be mixed with a liquid (diluent) before using it. When using injections by yourself, be sure you understand how to properly mix and store the medicine.

Prepare an injection only when you are ready to give it. Do not use if the medicine looks cloudy, has changed colors, or has particles in it. Call your pharmacist for new medicine.

If you need surgery, dental work, or a medical procedure, you may need to stop using Cablivi for at least 7 days ahead. Tell any doctor or dentist who treats you that you currently use this medicine.

Store Cablivi in its original carton in the refrigerator. Protect from light and do not freeze.

You may store an unopened Cablivi carton at room temperature for up to 2 months. Keep track of when you took the carton out of the refrigerator, and do not return it to the refrigerator once the medicine has reached room temperature.

If you cannot use the mixed medicine right away, store it in the refrigerator and use it within 4 hours.

Each vial (bottle) is for one use only. Throw it away after one use, even if there is still medicine left inside.

Use a needle and syringe only once and then place them in a puncture-proof "sharps" container. Follow state or local laws about how to dispose of this container. Keep it out of the reach of children and pets.

Warnings

Cablivi can increase your risk of bleeding. Call your doctor if you have unusual bruising or bleeding, or any bleeding that will not stop.

What other drugs will affect Cablivi

Tell your doctor about all your other medicines, especially:

a blood thinner--Warfarin, Coumadin, Jantoven; or

any medicine used to treat or prevent blood clots.

This list is not complete. Other drugs may affect Cablivi, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.