ChloraPrep One-Step

Generic name: Chlorhexidine Topical
Drug class: Antiseptic and germicides

Usage of ChloraPrep One-Step

Chlorhexidine is an antiseptic that fights bacteria.

ChloraPrep One-Step (for the skin) is used to clean the skin to prevent infection that may be caused by surgery, injection, or skin injury.

ChloraPrep One-Step may also be used for purposes not listed in this medication guide.

ChloraPrep One-Step side effects

Chlorhexidine can cause a rare but serious allergic reaction that may be life-threatening. Get emergency medical help if you have signs of an allergic reaction: hives, severe skin rash; wheezing, difficult breathing; cold sweats, severe dizziness; swelling of your face, lips, tongue, or throat.

ChloraPrep One-Step may cause serious side effects. Stop using ChloraPrep One-Step and call your doctor at once if you have:

  • severe burning, itching, or redness;
  • blistering or peeling;
  • swelling or severe skin rash; or
  • any other severe irritation of treated skin.
  • Less serious side effects are more likely, and you may have none at all.

    This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking ChloraPrep One-Step

    You should not use ChloraPrep One-Step if you are allergic to it.

    Ask a doctor or pharmacist if it is safe for you to use ChloraPrep One-Step if you have any allergies to food, dyes, animals, or medicines.

    It is not known whether ChloraPrep One-Step will harm an unborn baby. Tell your doctor if you are pregnant.

    It is not known whether Chlorhexidine topical passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.

    Be very careful when using ChloraPrep One-Step on a child younger than 2 months old. This medicine may cause severe irritation or chemical burns on a very young child.

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    How to use ChloraPrep One-Step

    Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

    Do not take by mouth. ChloraPrep One-Step is for use only on the skin.

    Rinse the skin before applying ChloraPrep One-Step. Apply only enough medicine to cover the area you are treating. Do not apply this medicine to deep cuts, scrapes, or open skin wounds.

    To use ChloraPrep One-Step soap, apply only enough to cover the area you are treating. Wash the area gently, then rinse thoroughly with plain water. Avoid using over large areas of skin.

    This medicine is made under sterile conditions, but its contents are not sterilized. It is possible for bacteria to get inside the product and contaminate it, which could spread infection. To avoid contaminating your medicine with bacteria:

  • Use only the swab, pad, or applicator provided with your medicine.
  • If no applicator is provided, use only a clean cotton ball or cotton swab to apply this medicine.
  • Do not touch the tip of the medicine bottle with your fingers or touch it to your skin.
  • Do not dilute the medicine with water or other liquid.
  • Use the applicator (pad, swab, or other dressing) only once. Throw away after one use.
  • Call your doctor if your symptoms do not improve, or if they get worse while using ChloraPrep One-Step.

    Store at room temperature away from moisture and heat. Do not freeze. Keep the bottle tightly closed when not in use.

    If this medicine is packaged in a single-use foil wrapper or other container, use it only once. Throw away after one use, even if there is still medicine left in it. Do not save for later use.


    Chlorhexidine can cause a rare but serious allergic reaction that may be life-threatening. Get emergency medical help if you have: hives, severe skin rash; wheezing, difficult breathing; cold sweats, severe dizziness; swelling of your face, lips, tongue, or throat.

    What other drugs will affect ChloraPrep One-Step

    It is not likely that other drugs you take orally or inject will have an effect on topically applied chlorhexidine. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.


    Every effort has been made to ensure that the information provided by is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. information has been compiled for use by healthcare practitioners and consumers in the United States and therefore does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise.'s drug information does not endorse drugs, diagnose patients or recommend therapy.'s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of information provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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