Fluconazole (Intravenous)

Generic name: Fluconazole
Drug class: Azole antifungals

Usage of Fluconazole (Intravenous)

Fluconazole injection is used to treat serious fungal or yeast infections, including oropharyngeal candidiasis (thrush, oral thrush), esophageal candidiasis (candida esophagitis), other candida infections (including urinary tract infections, peritonitis [inflammation of the lining of the stomach], and infections that may occur in different parts of the body), or fungal (cryptococcal) meningitis. This medicine works by killing the fungus or yeast, or preventing its growth.

Fluconazole injection is also used to prevent candidiasis in patients having bone marrow transplants, who receive cancer or radiation treatment.

This medicine is to be given only by or under the direct supervision of a doctor.

Fluconazole (Intravenous) side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Rare

Chest tightness

chills

clay-colored stools

cough

dark urine

diarrhea

difficulty with swallowing

dizziness

fast heartbeat

fever

headache

hives, itching, or skin rash

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

light-colored stools

loss of appetite

nausea and vomiting

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

stomach pain, continuing

unpleasant breath odor

unusual tiredness or weakness

upper right abdominal or stomach pain

vomiting of blood

yellow eyes and skin

Incidence not known

Black, tarry stools

blistering, peeling, or loosening of the skin

chest pain or discomfort

decreased urine

dry mouth

fainting

hoarseness

increased thirst

irregular or slow heart rate

joint or muscle pain

loss of bladder control

lower back or side pain

mood changes

muscle pain or cramps

muscle spasm or jerking of all extremities

numbness or tingling in the hands, feet, or lips

painful or difficult urination

pale skin

red skin lesions, often with a purple center

red, irritated eyes

seizures

sore throat

sores, ulcers, or white spots in the mouth or on the lips

sudden loss of consciousness

swollen glands

unusual bleeding or bruising

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Fearfulness, suspiciousness, or other mental changes

seeing, hearing, or feeling things that are not there

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Acid or sour stomach

belching

change in taste or bad, unusual, or unpleasant (after) taste

heartburn

indigestion

stomach discomfort or upset

Incidence not known

Hair loss or thinning of the hair

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Fluconazole (Intravenous)

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of fluconazole injection in children 6 months to 13 years of age. However, safety and efficacy have not been established in children younger than 6 months of age.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of fluconazole injection in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment in the dose for patients receiving fluconazole injection.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Alfuzosin

Amiodarone

Aripiprazole

Aripiprazole Lauroxil

Artemether

Atazanavir

Bedaquiline

Bepridil

Buprenorphine

Cisapride

Citalopram

Clarithromycin

Clozapine

Crizotinib

Dabrafenib

Dasatinib

Dofetilide

Domperidone

Donepezil

Dronedarone

Ebastine

Eliglustat

Encorafenib

Entrectinib

Erythromycin

Escitalopram

Etrasimod

Flibanserin

Glasdegib

Granisetron

Haloperidol

Iloperidone

Itraconazole

Ivabradine

Ivosidenib

Ketoconazole

Lapatinib

Levoketoconazole

Levomethadyl

Lomitapide

Lopinavir

Lumefantrine

Macimorelin

Mavacamten

Mefloquine

Mesoridazine

Methadone

Mifepristone

Mirtazapine

Mobocertinib

Nelfinavir

Nilotinib

Ondansetron

Osilodrostat

Panobinostat

Pazopanib

Pimavanserin

Pimozide

Piperaquine

Pitolisant

Propafenone

Quetiapine

Quinidine

Quinine

Ranolazine

Ribociclib

Ritonavir

Saquinavir

Selpercatinib

Solifenacin

Sorafenib

Sparfloxacin

Sunitinib

Tacrolimus

Tamoxifen

Telaprevir

Telithromycin

Thioridazine

Toremifene

Trazodone

Vandetanib

Vardenafil

Vemurafenib

Vilanterol

Vinflunine

Voclosporin

Voriconazole

Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Abrocitinib

Acalabrutinib

Acenocoumarol

Adagrasib

Ajmaline

Alfentanil

Alprazolam

Amisulpride

Amitriptyline

Amoxapine

Anagrelide

Anisindione

Apixaban

Apomorphine

Aprepitant

Aprindine

Arsenic Trioxide

Asenapine

Atorvastatin

Avanafil

Avapritinib

Avatrombopag

Azilsartan

Azilsartan Medoxomil

Azithromycin

Benzhydrocodone

Bretylium

Brotizolam

Buserelin

Carvedilol

Cerivastatin

Chloral Hydrate

Chloroquine

Chlorpromazine

Cilostazol

Ciprofloxacin

Clobazam

Clofazimine

Clomipramine

Clopidogrel

Clothiapine

Cobimetinib

Codeine

Colchicine

Conivaptan

Cyclobenzaprine

Cyclosporine

Daridorexant

Darifenacin

Darunavir

Deflazacort

Degarelix

Delamanid

Desipramine

Deslorelin

Dibenzepin

Dicumarol

Dihydrocodeine

Dihydroergotamine

Disopyramide

Dolasetron

Doxepin

Doxorubicin

Doxorubicin Hydrochloride Liposome

Droperidol

Efavirenz

Elacestrant

Eletriptan

Elexacaftor

Elvitegravir

Enflurane

Eplerenone

Ergoloid Mesylates

Ergonovine

Ergotamine

Eribulin

Etravirine

Everolimus

Famotidine

Fedratinib

Felbamate

Felodipine

Fentanyl

Finerenone

Fingolimod

Flecainide

Fluoxetine

Flurbiprofen

Fluticasone

Fluvastatin

Formoterol

Fosaprepitant

Foscarnet

Fosphenytoin

Galantamine

Gatifloxacin

Gemifloxacin

Gepirone

Gliclazide

Glimepiride

Glipizide

Glyburide

Gonadorelin

Goserelin

Halothane

Hexobarbital

Histrelin

Hydrocodone

Hydroquinidine

Hydroxychloroquine

Hydroxyzine

Ibrexafungerp

Ibrutinib

Ibuprofen

Ibutilide

Ifosfamide

Imipramine

Indinavir

Infigratinib

Inotuzumab Ozogamicin

Irbesartan

Isavuconazonium Sulfate

Isoflurane

Isradipine

Ivacaftor

Lansoprazole

Larotrectinib

Lefamulin

Lemborexant

Lenvatinib

Leuprolide

Levofloxacin

Levomilnacipran

Lidoflazine

Lofexidine

Lorcainide

Lorlatinib

Lornoxicam

Lovastatin

Lumateperone

Lurasidone

Lurbinectedin

Macitentan

Maraviroc

Meloxicam

Meperidine

Mephenytoin

Mephobarbital

Meprobamate

Methotrexate

Methotrimeprazine

Methylergonovine

Metronidazole

Midazolam

Midostaurin

Milnacipran

Mitapivat

Mizolastine

Moricizine

Moxifloxacin

Nafarelin

Naloxegol

Naproxen

Nevirapine

Nifedipine

Nisoldipine

Nitrofurantoin

Norfloxacin

Nortriptyline

Octreotide

Ofloxacin

Olanzapine

Olaparib

Omaveloxolone

Omeprazole

Osimertinib

Ospemifene

Oxaliplatin

Oxycodone

Ozanimod

Paclitaxel

Paliperidone

Palovarotene

Pantoprazole

Papaverine

Parecoxib

Paritaprevir

Paroxetine

Pasireotide

Pemigatinib

Pentamidine

Pentazocine

Perphenazine

Pexidartinib

Phenindione

Phenobarbital

Phenprocoumon

Phenytoin

Pipamperone

Pirmenol

Piroxicam

Ponesimod

Posaconazole

Prajmaline

Pralsetinib

Primidone

Probucol

Procainamide

Prochlorperazine

Proguanil

Promethazine

Protriptyline

Quizartinib

Rabeprazole

Rifabutin

Rimegepant

Risperidone

Ruxolitinib

Selumetinib

Sertindole

Sertraline

Sevoflurane

Sildenafil

Simeprevir

Simvastatin

Siponimod

Sirolimus

Sirolimus Protein-Bound

Sodium Phosphate

Sodium Phosphate, Dibasic

Sodium Phosphate, Monobasic

Sonidegib

Sotalol

Sparsentan

Spiramycin

Sufentanil

Sulfamethoxazole

Sulpiride

Sultopride

Tazemetostat

Telavancin

Temsirolimus

Terfenadine

Tetrabenazine

Tezacaftor

Theophylline

Ticagrelor

Tilidine

Tipranavir

Tofacitinib

Tolbutamide

Tolterodine

Tolvaptan

Torsemide

Tramadol

Triazolam

Triclabendazole

Trifluoperazine

Trimethoprim

Trimipramine

Triptorelin

Ubrogepant

Ulipristal

Valdecoxib

Venetoclax

Venlafaxine

Verapamil

Vinblastine

Vincristine

Vincristine Sulfate Liposome

Vinorelbine

Vorinostat

Vortioxetine

Warfarin

Zanubrutinib

Zidovudine

Zolmitriptan

Zolpidem

Zotepine

Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Amlodipine

Atevirdine

Losartan

Nicardipine

Prednisone

Ramelteon

Rifampin

Rifapentine

Rivaroxaban

Suvorexant

Tretinoin

Trimetrexate

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Relate drugs

How to use Fluconazole (Intravenous)

A nurse or other trained health professional will give you or your child this medicine. This medicine is given through a needle placed in one of your veins.

Your doctor will give you or your child a few doses of this medicine until your condition improves, and then switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

Warnings

It is very important that your doctor check the progress of you or your child at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

If your or your child's symptoms do not improve, or if they become worse, check with your doctor. You may need to use this medicine for several months before your infection gets better.

You or your child should not use erythromycin (Ery-Tab®), pimozide (Orap®), or quinidine (Cardioquin®) while receiving this medicine because of the risk of unwanted side effects.

Using this medicine for a long time or using it too much while you are pregnant (especially during the first trimester) can harm your unborn baby. Use an effective form of birth control during treatment with this medicine and for at least 1 week after the last dose. If you think you have become pregnant while using this medicine, tell your doctor right away.

This medicine may rarely cause serious liver problems. Check with your doctor right away if you or your child have stomach pain or tenderness, clay-colored stools, dark urine, decreased appetite, fever, headache, itching, loss of appetite, nausea and vomiting, skin rash, swelling of the feet or lower legs, unusual tiredness or weakness, or yellow eyes or skin.

This medicine may rarely cause a serious type of allergic reaction, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you or your child have a rash, itching, swelling of the face, tongue, and throat, trouble breathing, or chest pain after you receive the medicine.

Serious skin reactions can occur in certain people during treatment with this medicine. Check with your doctor right away if you or your child start having a skin rash, itching, or any other skin changes while you are using this medicine.

Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem including QT prolongation.

This medicine may cause adrenal gland problems. Check with your doctor right away if you have darkening of the skin, diarrhea, dizziness, fainting, loss of appetite, mental depression, nausea, skin rash, unusual tiredness or weakness, or vomiting.

This medicine may cause some people to become dizzy, drowsy, or less alert than they are normally. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

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