Lumateperone

Generic name: Lumateperone
Brand names: Caplyta
Dosage form: oral capsule (10.5 mg; 21 mg; 42 mg)
Drug class: Atypical antipsychotics

Usage of Lumateperone

Lumateperone is used in adults to treat schizophrenia.

Lumateperone is also used alone or with lithium or valproate to treat depression with bipolar disorder (manic depression).

Lumateperone may also be used for purposes not listed in this medication guide.

Lumateperone side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

People with depression or mental illness may have thoughts about suicide. Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Stay alert to changes in your mood or symptoms. Your family or caregivers should also watch for sudden changes in your behavior.

High doses or long-term use of lumateperone can cause a serious movement disorder that may not be reversible. The longer you use lumateperone, the more likely you are to develop this disorder, especially if you are a woman or an older adult.

Lumateperone may cause serious side effects. Call your doctor at once if you have:

feeling unsteady, feeling like you might pass out;

uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);

tightness in your neck or throat, trouble swallowing;

trouble breathing or speaking;

a seizure;

high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor;

low white blood cell counts--fever, chills, mouth sores, skin sores, sore throat, cough, trouble breathing; or

severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Common side effects of lumateperone may include:

nausea;

dizziness;

drowsiness; or

dry mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Lumateperone

You should not use lumateperone if you are allergic to it.

Lumateperone may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use.

Tell your doctor if you have or have ever had:

heart problems or a stroke;

high or low blood pressure;

seizures;

trouble swallowing;

low white blood cell count;

high cholesterol or triglycerides;

diabetes or high blood sugar, or a family history of diabetes or high blood sugar; or

liver or kidney disease.

Taking antipsychotic medicine in the last 3 months of pregnancy may cause serious problems in the newborn. Tell your doctor right away if you get pregnant. Do not stop the medicine without your doctor's advice.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of lumateperone on the baby.

You should not breastfeed while using lumateperone.

lumateperone may affect fertility (your ability to have children), whether you are a man or a woman.

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How to use Lumateperone

Usual Adult Dose for Schizophrenia:

42 mg orally once a dayUse: For the treatment of schizophrenia

Usual Adult Dose for Bipolar Disorder:

42 mg orally once a dayUse: As monotherapy or as adjunctive therapy with lithium or valproate, for the treatment of depressive episodes associated with bipolar I or II disorder (bipolar depression)

Warnings

Lumateperone is not approved for use in older adults with dementia-related psychosis.

People with depression or mental illness may have thoughts about suicide. Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Tell your doctor right away if you have any sudden changes in mood or behavior, or thoughts about suicide.

What other drugs will affect Lumateperone

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your current medicines. Many drugs can affect lumateperone, especially:

an antibiotic, antifungal, or antiviral medicine;

blood pressure medication;

bronchodilator asthma medication;

cold or allergy medicine (Benadryl and others);

medicine to treat depression, anxiety, mood disorders, or mental illness;

medicine to treat overactive bladder;

medicine to treat Parkinson's disease;

medicine to treat stomach problems, motion sickness, or irritable bowel syndrome;

seizure medicine; or

St. John's wort.

This list is not complete and many other drugs may affect lumateperone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

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