Mesnex oral/injection

Generic name: Mesna (oral/injection)
Brand names: Mesnex
Drug class: Antineoplastic detoxifying agents

Usage of Mesnex oral/injection

Mesnex is used to prevent bleeding in the bladder (hemorrhagic cystitis) during chemotherapy with ifosfamide (Ifex).

Mesnex will not prevent other side effects caused by ifosfamide.

Mesnex may also be used for purposes not listed in this medication guide.

Mesnex oral/injection side effects

Get emergency medical help if you have signs of an allergic reaction or severe skin reaction:

  • fever, nausea, vomiting, joint or muscle pain;
  • hives, rash or redness, skin pain or swelling, blisters or peeling;
  • feeling light-headed, trouble breathing;
  • racing heartbeats; or
  • mouth sores, or swelling in your face or throat.
  • Mesnex may cause serious side effects. Call your doctor at once if you have:

  • chest pain, trouble breathing;
  • easy bruising or bleeding (nosebleeds, bleeding gums);
  • low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet; or
  • low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling.
  • Common side effects of Mesnex may include:

  • nausea, vomiting, stomach pain, loss of appetite;
  • diarrhea, constipation;
  • weakness, tiredness, drowsiness;
  • headache;
  • hair loss; or
  • fever, flu-like symptoms.
  • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Mesnex oral/injection

    You should not use Mesnex if you are allergic to Mesnex, edetate sodium, sodium hydroxide, or Benzyl Alcohol.

    Tell your doctor if you are allergic to any medicine.

    Although Mesnex is not expected to harm an unborn baby, ifosfamide can harm an unborn baby if the mother or the father is using this medicine.

  • If you are a woman, you may need to have a negative pregnancy test before starting this treatment with ifosfamide. Use effective birth control to prevent pregnancy while you are using ifosfamide and for at least 6 months after your last dose.
  • If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose of ifosfamide.
  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using ifosfamide.
  • Do not breast-feed while using Mesnex or ifosfamide, and for at least 1 week after your last dose.

    Mesnex injection contains an ingredient that can cause serious side effects or death in premature or low-birthweight babies. This medicine tablets do not contain this ingredient. This medicine injection should not be given to a premature or low birth weight infant.

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    How to use Mesnex oral/injection

    Before and during treatment with Mesnex, you may need frequent urine tests.

    Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

    Mesnex injection is given as an infusion into a vein. A healthcare provider will give you this injection at the same time you receive ifosfamide.

    Oral Mesnex is taken by mouth, usually 2 and 6 hours after you receive ifosfamide.

    Mesnex is given either in a series of 3 injections spaced 4 hours apart, or as a single injection followed by 2 oral doses spaced 2 and 6 hours later.

    Follow your doctor's dosing instructions very carefully.

    Call your doctor if you vomit within 2 hours after taking oral Mesnex. You may need to take another oral dose or receive a this medicine injection.

    Tell your doctor if you have red or pink colored urine. This may be a sign that your ifosfamide dose needs to be changed.

    Drink at least 1 to 2 liters (32 to 64 ounces) of liquid each day while you are using Mesnex.

    This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Mesnex.

    Store Mesnex tablets at room temperature away from moisture and heat.


    Get emergency medical help if you have signs of a serious reaction: fever, nausea, vomiting, racing heartbeats, hives, rash or redness, skin pain or swelling, blisters or peeling, joint or muscle pain, feeling light-headed, trouble breathing, mouth sores, or swelling in your face or throat.

    What other drugs will affect Mesnex oral/injection

    Other drugs may affect Mesnex, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.


    Every effort has been made to ensure that the information provided by is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. information has been compiled for use by healthcare practitioners and consumers in the United States and therefore does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise.'s drug information does not endorse drugs, diagnose patients or recommend therapy.'s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of information provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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