Olanzapine (Intramuscular)

Generic name: Olanzapine
Drug class: Atypical antipsychotics

Usage of Olanzapine (Intramuscular)

Olanzapine injection is used to treat agitation that occurs with schizophrenia and bipolar mania. This medicine should not be used to treat behavioral problems in older adult patients who have dementia or Alzheimer's disease.

Zyprexa® IntraMuscular injection is to be given only by or under the direct supervision of a doctor.

Zyprexa® Relprevv™ is available only under a special restricted distribution program called Zyprexa® Relprevv™ patient care program.

Olanzapine (Intramuscular) side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Bloating or swelling of the face, arms, hands, lower legs, or feet

blurred vision

change in vision

change in walking and balance

clumsiness or unsteadiness

difficulty with speaking

difficulty with swallowing

drooling

impaired vision

inability to sit still

loss of balance control

mask-like face

muscle trembling, jerking, or stiffness

need to keep moving

rapid weight gain

restlessness

shakiness in the legs, arms, hands, or feet

shuffling walk

slowed movements

slurred speech

stiffness of the arms and legs

tic-like (jerky) movements of the head, face, mouth, and neck

tingling of the hands or feet

trembling or shaking of the fingers, hands, or feet

twisting movements of the body

uncontrolled movements, especially of the face, neck, and back

unusual weight gain or loss

Less common

Bladder pain

bloody or cloudy urine

bruising

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chest pain

difficult or labored breathing

difficult, burning, or painful urination

dizziness

excessive muscle tone

frequent urge to urinate

headache

inability to move the eyes

increased blinking or spasms of the eyelid

itching of the vagina or genital area

lack of coordination

large, flat, blue, or purplish patches in the skin

loss of bladder control

loss of memory

lower back or side pain

muscle tension or tightness

nervousness

pain, redness, and swelling at the injection site

pounding in the ears

problems with memory

rhythmic movement of the muscles

slow, fast, pounding, or irregular heartbeat or pulse

speaking is less clear than usual

sticking out the tongue

thick, white vaginal discharge with no odor or with a mild odor

tightness in the chest

trouble with breathing, speaking, or swallowing

twitching

uncontrolled twisting movements of the neck, trunk, arms, or legs

unusual or incomplete body or facial movements

weakness of the arms and legs

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Acid or sour stomach

back pain

belching

change in personality

difficulty having a bowel movement (stool)

discouragement

feeling sad or empty

fever

heartburn

increased appetite

increased cough

indigestion

lack of appetite

lack or loss of strength

loss of interest or pleasure

runny nose

sneezing

stomach discomfort, upset, or pain

stuffy nose

thirst

trouble sleeping

trouble with concentrating

watering of the mouth

weight gain

Less common

Body aches or pain

chills

cold sweats

congestion

cough

dry skin

dryness or soreness of the throat

false or unusual sense of well-being

heavy menstrual bleeding

hoarseness

joint pain

lack of feeling or emotion

leg cramps

pain in the arms or legs

sweating

tender, swollen glands in the neck

uncaring feelings

voice change

vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Olanzapine (Intramuscular)

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of olanzapine injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of olanzapine injection in the elderly. However, elderly patients are more likely to have dementia or age-related liver, kidney, or heart problems, which may require caution or an adjustment in the dose for patients receiving olanzapine injection.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Bepridil

Bromopride

Cisapride

Dronedarone

Levoketoconazole

Levomethadyl

Metoclopramide

Pimozide

Piperaquine

Potassium Citrate

Saquinavir

Sparfloxacin

Terfenadine

Thioridazine

Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Abametapir

Acepromazine

Adagrasib

Alfentanil

Alfuzosin

Alprazolam

Amantadine

Amiodarone

Amisulpride

Amitriptyline

Amobarbital

Anagrelide

Anileridine

ApalUTAmide

Apomorphine

Apomorphine Hydrochloride

Aripiprazole

Aripiprazole Lauroxil

Arsenic Trioxide

Asenapine

Astemizole

Atazanavir

Azithromycin

Baclofen

Bedaquiline

Benperidol

Benzhydrocodone

Bromazepam

Bromocriptine Mesylate

Buprenorphine

Bupropion

Buserelin

Buspirone

Butabarbital

Butorphanol

Cabergoline

Calcium Oxybate

Cannabidiol

Cannabis

Capmatinib

Carbamazepine

Carbinoxamine

Carisoprodol

Carphenazine

Ceritinib

Cetirizine

Chloral Hydrate

Chlordiazepoxide

Chloroquine

Chlorpromazine

Chlorzoxazone

Ciprofloxacin

Citalopram

Clarithromycin

Clobazam

Clofazimine

Clomipramine

Clonazepam

Clorazepate

Clothiapine

Clozapine

Cobicistat

Codeine

Crizotinib

Cyclobenzaprine

Dabrafenib

Daridorexant

Dasatinib

Degarelix

Delamanid

Desipramine

Deslorelin

Deutetrabenazine

Dexmedetomidine

Diacetylmorphine

Diazepam

Dichloralphenazone

Difenoxin

Dihydrocodeine

Diphenhydramine

Diphenoxylate

Disopyramide

Dofetilide

Dolasetron

Domperidone

Donepezil

Doxepin

Doxylamine

Droperidol

Ebastine

Efavirenz

Encorafenib

Enflurane

Enoxacin

Entrectinib

Enzalutamide

Eribulin

Erythromycin

Escitalopram

Esketamine

Estazolam

Eszopiclone

Ethchlorvynol

Ethopropazine

Ethylmorphine

Etrasimod

Famotidine

Felbamate

Fenoldopam Mesylate

Fentanyl

Fexinidazole

Fingolimod

Flecainide

Flibanserin

Fluconazole

Flunitrazepam

Fluoxetine

Fluphenazine

Flurazepam

Fluspirilene

Fluvoxamine

Formoterol

Foscarnet

Fosphenytoin

Fospropofol

Fostemsavir

Gabapentin

Gabapentin Enacarbil

Galantamine

Gatifloxacin

Gemifloxacin

Gepirone

Glasdegib

Glucagon

Glycopyrrolate

Glycopyrronium Tosylate

Gonadorelin

Goserelin

Granisetron

Halazepam

Halofantrine

Haloperidol

Halothane

Hexobarbital

Histrelin

Hydrocodone

Hydromorphone

Hydroquinidine

Hydroxychloroquine

Hydroxyzine

Ibutilide

Iloperidone

Imipramine

Inotuzumab Ozogamicin

Isoflurane

Itraconazole

Ivabradine

Ivosidenib

Ketamine

Ketazolam

Ketobemidone

Ketoconazole

Lacosamide

Lapatinib

Lefamulin

Lemborexant

Lenvatinib

Leuprolide

Levocetirizine

Levodopa

Levofloxacin

Levorphanol

Lithium

Lofexidine

Lorazepam

Loxapine

Lumacaftor

Lumefantrine

Macimorelin

Magnesium Oxybate

Meclizine

Mefloquine

Melperone

Meperidine

Mephobarbital

Meprobamate

Meptazinol

Mesoridazine

Metaxalone

Methacholine

Methadone

Methdilazine

Methocarbamol

Methohexital

Methotrimeprazine

Methylene Blue

Metronidazole

Midazolam

Mifepristone

Mirtazapine

Mitotane

Mizolastine

Mobocertinib

Molindone

Moricizine

Morphine

Morphine Sulfate Liposome

Moxifloxacin

Nafarelin

Nalbuphine

Nelfinavir

Nicomorphine

Nilotinib

Nitrazepam

Nitrous Oxide

Norfloxacin

Octreotide

Ofloxacin

Omeprazole

Ondansetron

Opium

Opium Alkaloids

Orphenadrine

Osilodrostat

Osimertinib

Oxaliplatin

Oxazepam

Oxycodone

Oxymorphone

Ozanimod

Pacritinib

Paliperidone

Panobinostat

Papaveretum

Paregoric

Pentamidine

Pentazocine

Pentobarbital

Perampanel

Perazine

Periciazine

Perphenazine

Phenobarbital

Phenytoin

Pimavanserin

Pipamperone

Piperacetazine

Pipotiazine

Piritramide

Pitolisant

Pixantrone

Ponesimod

Posaconazole

Potassium Oxybate

Pramipexole Dihydrochloride

Prazepam

Pregabalin

Primidone

Probucol

Procainamide

Prochlorperazine

Promazine

Promethazine

Propafenone

Propofol

Protriptyline

Quazepam

Quetiapine

Quinidine

Quinine

Quizartinib

Ramelteon

Ranolazine

Relugolix

Remifentanil

Remimazolam

Remoxipride

Revefenacin

Ribociclib

Rifampin

Risperidone

Ritonavir

Ropeginterferon Alfa-2b-njft

Ropinirole Hydrochloride

Rotigotine

Scopolamine

Secobarbital

Secretin Human

Selpercatinib

Sertindole

Sertraline

Sevoflurane

Siponimod

Sodium Oxybate

Sodium Phosphate

Sodium Phosphate, Dibasic

Sodium Phosphate, Monobasic

Solifenacin

Sorafenib

Sotalol

St John's Wort

Sufentanil

Sulpiride

Sultopride

Sunitinib

Suvorexant

Tacrolimus

Tamoxifen

Tapentadol

Telaprevir

Telavancin

Telithromycin

Temazepam

Tetrabenazine

Thiethylperazine

Thiopental

Thiopropazate

Tilidine

Tiotropium

Tizanidine

Tolonium Chloride

Tolterodine

Topiramate

Toremifene

Tramadol

Trazodone

Triazolam

Triclabendazole

Trifluoperazine

Trifluperidol

Triflupromazine

Trimeprazine

Trimipramine

Triptorelin

Vandetanib

Vardenafil

Vemurafenib

Venlafaxine

Vilanterol

Vinflunine

Voclosporin

Voriconazole

Vorinostat

Zaleplon

Zolpidem

Zopiclone

Zotepine

Zuclopenthixol

Zuranolone

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Amprenavir

Betel Nut

Fosamprenavir

Valproic Acid

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Ethanol

Tobacco

Relate drugs

How to use Olanzapine (Intramuscular)

A nurse or other trained health professional will give you this medicine in a clinic, community health center, or hospital. This medicine is given as a shot into a muscle.

Your doctor may give you a few doses of this medicine until your condition improves, and then switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

Use only the brand of this medicine that your doctor prescribed. Different brands may not work the same way.

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Tell your doctor if you smoke tobacco. You might need a different amount of this medicine if you smoke.

Warnings

It is very important that your doctor check your progress while you are receiving this medicine to make sure it is working properly. Blood tests may be needed to check for unwanted effects.

Olanzapine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you or your caregiver notice any of these unwanted effects, tell your doctor right away.

This medicine may cause a condition called drug reaction with eosinophilia and systemic symptoms (DRESS). Call your doctor right away if you have a rash, red, swollen skin, fever, chills, cough, trouble breathing, swollen glands, or unusual bleeding, bruising, or weakness after receiving this medicine.

This medicine may increase your cholesterol and fats in the blood. If this condition occurs, your doctor may give you some medicines that can lower the amount of cholesterol and fats in the blood.

This medicine may increase your weight. Your doctor may need to check your weight regularly during treatment with this medicine.

This medicine may increase the amount of sugar in your blood. Check with your doctor right away if you have increased thirst or increased urination. If you have diabetes, you may notice a change in the results of your urine or blood sugar tests. If you have any questions, check with your doctor.

Check with your doctor right away if you have difficulty with breathing, a fast heartbeat, a high fever, high or low blood pressure, increased sweating, loss of bladder control, seizures, severe muscle stiffness, unusually pale skin, or tiredness. These could be symptoms of a serious condition called neuroleptic malignant syndrome (NMS).

This medicine may cause tardive dyskinesia (a movement disorder). Check with your doctor right away if you have lip smacking or puckering, puffing of the cheeks, rapid or worm-like movements of the tongue, uncontrolled chewing movements, or uncontrolled movements of the arms and legs.

Olanzapine injection may cause drowsiness, trouble with thinking, trouble with controlling body movements, or trouble with your vision, which may lead to falls, fractures, or other injuries. Make sure you know how you react to this medicine before you drive, use machines, or do other jobs that require you to be alert, well-coordinated, or able to think or see well.

Dizziness, lightheadedness, or fainting may occur, especially when you get up from a lying or sitting position. Getting up slowly may help. If this problem continues or gets worse, check with your doctor.

This medicine may cause post-injection delirium/sedation syndrome. Tell your doctor right away if you have dizziness, drowsiness, sleepiness, seizures, or confusion as to time, place, or person after receiving the injection.

This medicine can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.

This medicine may make it more difficult for your body to cool down. It might reduce how much you sweat. Your body could get too hot if you do not sweat enough. If your body gets too hot, you might feel dizzy, weak, tired, or confused. You might vomit or have an upset stomach. Do not get too hot while you are exercising. Avoid places that are very hot. Call your doctor if you are too hot and can not cool down.

Avoid drinking alcohol while you are receiving this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines) and herbal or vitamin supplements.

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