Secuado

Generic name: Asenapine
Drug class: Atypical antipsychotics

Usage of Secuado

Asenapine skin patch is used to treat schizophrenia. This medicine should not be used to treat behavioral problems in older adult patients who have dementia.

This medicine is available only with your doctor's prescription.

Secuado side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Abdominal or stomach pain

blurred vision

dry mouth

flushed, dry skin

fruit-like breath odor

inability to move the eyes

increased blinking or spasms of the eyelid

increased hunger

increased thirst

increased urination

nausea

sticking out of the tongue

sweating

trouble breathing, speaking, or swallowing

uncontrolled twisting movements of the neck, trunk, arms, or legs

unexplained weight loss

unusual facial expressions

vomiting

Incidence not known

Black, tarry stools

chest pain

chills

cold sweats

confusion

convulsions

cough or hoarseness

difficulty in moving

dizziness, faintness, or lightheadedness when getting up from lying or sitting position

fainting

fast, pounding, or irregular heartbeat or pulse

fever with or without chills

high fever

high or low blood pressure

hives, itching, skin rash

joint pain

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

lip smacking or puckering

loss of bladder control

lower back or side pain

muscle aching or cramping

muscle pains or stiffness

painful or difficult urination

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

rapid or worm-like movements of the tongue

severe muscle stiffness

sore throat

sores, ulcers, or white spots on the lips or in the mouth

swollen glands

swollen joints

tightness in the chest

tiredness

uncontrolled chewing movements

uncontrolled movements of the arms and legs

unusual bleeding or bruising

unusual tiredness or weakness

unusually pale skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Difficulty having a bowel movement (stool)

difficulty in speaking

drooling

loss of balance control

muscle trembling, jerking, or stiffness

redness, itching, or swelling of the skin where the patch is applied

restlessness

shuffling walk

stiffness of the limbs

Less common

Acid or sour stomach

belching

diarrhea

heartburn

increased appetite

indigestion

sleepiness or unusual drowsiness

stomach discomfort, upset, or pain

stuffy or runny nose

Incidence not known

Dry mouth

lack or loss of strength

swelling of breasts or unusual milk production

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Secuado

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of asenapine skin patch in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of asenapine skin patch in the elderly.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Bepridil

Bromopride

Cisapride

Dronedarone

Levoketoconazole

Mesoridazine

Metoclopramide

Pimozide

Piperaquine

Saquinavir

Sparfloxacin

Terfenadine

Thioridazine

Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acecainide

Adagrasib

Ajmaline

Alfentanil

Alfuzosin

Alprazolam

Amiodarone

Amisulpride

Amitriptyline

Amoxapine

Anagrelide

Apomorphine

Aripiprazole

Aripiprazole Lauroxil

Arsenic Trioxide

Artemether

Astemizole

Atazanavir

Azimilide

Azithromycin

Bedaquiline

Benzhydrocodone

Bretylium

Bromazepam

Bunazosin

Buprenorphine

Buserelin

Butorphanol

Calcium Oxybate

Cannabidiol

Cannabis

Ceritinib

Cetirizine

Chloroquine

Chlorpromazine

Ciprofloxacin

Citalopram

Clarithromycin

Clobazam

Clofazimine

Clomipramine

Clonazepam

Clothiapine

Clozapine

Codeine

Crizotinib

Cyclobenzaprine

Dabrafenib

Daridorexant

Dasatinib

Degarelix

Delamanid

Desipramine

Deslorelin

Deutetrabenazine

Dexmedetomidine

Dihydrocodeine

Disopyramide

Dofetilide

Dolasetron

Domperidone

Donepezil

Doxazosin

Doxylamine

Droperidol

Duloxetine

Efavirenz

Eliglustat

Encorafenib

Enoxacin

Entrectinib

Erythromycin

Escitalopram

Esketamine

Etrasimod

Fentanyl

Fexinidazole

Fingolimod

Flecainide

Flibanserin

Fluconazole

Fluoxetine

Fluvoxamine

Formoterol

Foscarnet

Fostemsavir

Gabapentin

Gabapentin Enacarbil

Gatifloxacin

Gemifloxacin

Gepirone

Glasdegib

Gonadorelin

Goserelin

Granisetron

Halofantrine

Haloperidol

Histrelin

Hydrocodone

Hydromorphone

Hydroquinidine

Hydroxychloroquine

Hydroxyzine

Ibutilide

Iloperidone

Imipramine

Inotuzumab Ozogamicin

Ivabradine

Ivosidenib

Ketamine

Ketoconazole

Lacosamide

Lapatinib

Lefamulin

Lemborexant

Lenvatinib

Lofexidine

Lopinavir

Loxapine

Lumefantrine

Macimorelin

Magnesium Oxybate

Mefloquine

Meperidine

Methadone

Metronidazole

Mifepristone

Mirtazapine

Mobocertinib

Morphine

Morphine Sulfate Liposome

Moxifloxacin

Moxisylyte

Nafarelin

Nalbuphine

Nilotinib

Norfloxacin

Nortriptyline

Octreotide

Ofloxacin

Olanzapine

Ondansetron

Osilodrostat

Osimertinib

Oxaliplatin

Oxycodone

Oxymorphone

Ozanimod

Pacritinib

Paliperidone

Panobinostat

Paroxetine

Pasireotide

Pazopanib

Pentazocine

Periciazine

Phenobarbital

Phenoxybenzamine

Phentolamine

Pimavanserin

Pirmenol

Pitolisant

Ponesimod

Posaconazole

Potassium Oxybate

Prajmaline

Prazosin

Pregabalin

Primidone

Procainamide

Prochlorperazine

Promethazine

Propafenone

Protriptyline

Quetiapine

Quinidine

Quinine

Quizartinib

Ranolazine

Relugolix

Remifentanil

Remimazolam

Ribociclib

Risperidone

RoPeginterferon Alfa-2b-njft

Selpercatinib

Sematilide

Sertindole

Sertraline

Sevoflurane

Siponimod

Sodium Oxybate

Sodium Phosphate

Sodium Phosphate, Dibasic

Sodium Phosphate, Monobasic

Solifenacin

Sorafenib

Sotalol

Sufentanil

Sulpiride

Sultopride

Sunitinib

Tacrolimus

Tapentadol

Tedisamil

Telavancin

Telithromycin

Terazosin

Tetrabenazine

Topiramate

Toremifene

Tramadol

Trazodone

Triclabendazole

Trifluoperazine

Trimipramine

Triptorelin

Urapidil

Vandetanib

Vardenafil

Vemurafenib

Vilanterol

Vinflunine

Voclosporin

Voriconazole

Zolpidem

Zotepine

Zuclopenthixol

Zuranolone

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Relate drugs

How to use Secuado

Use this medicine exactly as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

This medicine comes with patient instructions. Read and follow the instructions carefully. Ask your doctor if you have any questions.

To use the Secuado® skin patch:

This medicine should only be used on skin that is not irritated or injured. Do not put the patch in your mouth, chew it, or swallow it.

Asenapine skin patches are packaged in sealed pouches. Do not cut open the foil pouch and remove the patch from the sealed pouch until you are ready to apply it.

Apply the patch to a dry, flat skin area on your upper arm, upper back, abdomen, or hips. Choose a place where the skin is not very oily and is free of scars, cuts, burns, or irritation.

Apply 1 patch to 1 application site every 24 hours. Rotate your application site every time you change a patch. Do not wear the patch longer than 24 hours.

If the patch lifts or falls off after applying it, throw it away and apply a new patch in the same area.

Do not shave the skin where you will apply the patch. You may cut the hair with a pair of scissors.

Avoid bathing or swimming while wearing the patch. You may take a shower while using it.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take Depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For transdermal dosage form (skin patch):

For schizophrenia:

Adults—At first, 1 patch (containing 3.8 milligrams (mg) of asenapine) every 24 hours. After 1 week, your doctor may increase your dose as needed and tolerated.

Children—Use and dose must be determined by your doctor.

Missed Dose

If you forget to wear or change a patch, put one on as soon as you can. If it is almost time to put on your next patch, wait until then to apply a new patch and skip the one you missed. Do not apply extra patches to make up for a missed dose.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

To dispose of the Secuado® patch, fold the patch in half with the sticky side inside. If the patch has not been used, take it out of the pouch and remove the liner that covers the sticky side of the patch before folding it in half. Ask your pharmacist about the best way to dispose of patches you do not use. Do not flush the pouch or the protective liner down the toilet. Put them in a trash can.

Warnings

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for any unwanted effects.

This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, dizziness or lightheadedness, trouble breathing, trouble swallowing, or any swelling of your hands, face, tongue, or throat while you are using this medicine.

Tell your doctor right away if you have sores or blisters in the mouth, or numbness or tingling of the mouth or throat after using this medicine.

Check with your doctor right away if you have any of the following symptoms while using this medicine: convulsions (seizures), difficulty with breathing, a fast heartbeat, a high fever, high or low blood pressure, increased sweating, loss of bladder control, severe muscle stiffness, unusually pale skin, or tiredness. These could be symptoms of a serious condition called neuroleptic malignant syndrome (NMS).

This medicine may cause tardive dyskinesia (a movement disorder). Check with your doctor right away if you have any of the following symptoms while using this medicine: lip smacking or puckering, puffing of the cheeks, rapid or worm-like movements of the tongue, uncontrolled chewing movements, or uncontrolled movements of the arms and legs.

For diabetic patients: This medicine may affect your blood sugar levels. Check with your doctor right away if you have increased thirst or increased urination. If you notice a change in the results of your urine or blood sugar tests, or if you have any questions, check with your doctor.

This medicine may increase your weight. Your doctor may need to check your weight on a regular basis while you are using this medicine. Talk to your doctor about ways to prevent weight gain.

Dizziness, lightheadedness, or fainting may occur, especially when you get up from a lying or sitting position suddenly. Getting up slowly may help. If this problem continues or gets worse, check with your doctor.

Asenapine can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. If you can, avoid people with infections. Check with your doctor right away if you think you are getting an infection, or if you have a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.

This medicine can cause changes in the heart rhythm, such as a condition called QT prolongation. It may change the way your heart beats and cause fainting or serious side effects. Contact your doctor right away if you have any symptoms of heart rhythm problems, such as fast, pounding, or irregular heartbeats.

This medicine may cause dizziness, drowsiness, trouble with thinking, or trouble with controlling body movements. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that requires you to be alert, well-coordinated, or able to think well.

This medicine might reduce how much you sweat. Your body could get too hot if you do not sweat enough. If your body gets too hot, you might feel dizzy, weak, tired, or confused. You might vomit or have an upset stomach. Do not get too hot while you are exercising. Avoid places that are very hot. Call your doctor if you are too hot and cannot cool down.

Heat can cause the asenapine in the patch to be absorbed into your body faster. This may increase the chance of serious side effects or an overdose. While you are using this medicine, do not use a heating pad, electric blanket, heat or tanning lamps, sauna, a sunlamp, or a heated water bed, and do not sunbathe, or take long baths or showers in hot water.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

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