Toprol XL

Generic name: Metoprolol Succinate Tablet, Extended Release
Drug class: Cardioselective beta blockers

Usage of Toprol XL

Toprol-XL is a beta-blocker that affects the heart and circulation (blood flow through arteries and veins).

Toprol-XL is used to treat angina (chest pain) and hypertension (high blood pressure).

Toprol-XL is also used to lower your risk of death or needing to be hospitalized for heart failure.

Toprol-XL may also be used for indications not in this medication guide.

Toprol XL side effects

Get emergency medical help if you have signs of an allergic reaction to Toprol-XL: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

very slow heartbeat, excessive tiredness, or chest pain;

a light-headed feeling, like you might pass out;

shortness of breath (even with mild exertion), swelling, rapid weight gain; or

cold feeling in your hands and feet.

Common Toprol-XL side effects may include:

dizziness, tired feeling;

depression, confusion, memory problems;

nightmares, trouble sleeping;

diarrhea; or

mild itching or rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Toprol XL

You should not use Toprol-XL if you are allergic to metoprolol, or other beta-blockers (atenolol, carvedilol, labetalol, nadolol, nebivolol, propranolol, sotalol, and others), or if you have:

a serious heart problem such as heart block greater than first degree or sick sinus syndrome without a pacemaker;

severe circulation problems;

severe heart failure (that required you to be in the hospital); or

a history of slow heart beats that have caused you to faint.

To make sure Toprol-XL is safe for you, tell your doctor if you have:

asthma, chronic obstructive pulmonary disease (COPD), sleep apnea, or other breathing disorder;

diabetes (taking Toprol-XL may make it harder for you to tell when you have low blood sugar);

liver disease;

congestive heart failure;

problems with circulation (such as Raynaud's syndrome);

peripheral vascular disease or claudication (pain in your legs when walking);

a thyroid disorder; or

pheochromocytoma (tumor of the adrenal gland); or

if you are planning major surgery or dental work.

Do not give Toprol-XL to a child without medical advice.

Tell your doctor about all medications you are taking before using Toprol-XL, especially any calcium channel blockers (including diltiazem, verapamil, and others).

Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether metoprolol succinate will harm an unborn baby. However, having high blood pressure during pregnancy may cause complications such as diabetes or eclampsia (dangerously high blood pressure that can lead to medical problems in both mother and baby). The benefit of treating hypertension may outweigh any risks to the baby.

Ask a doctor before using Toprol-XL if you are breast-feeding. Metoprolol succinate can pass into breast milk and may cause dry skin, dry mouth, diarrhea, constipation, or slow heartbeats in your baby.

Relate drugs

How to use Toprol XL

Usual Adult Dose for Hypertension:

Metoprolol succinate extended release tablets: Initial dose: 25 to 100 mg orally once a day Maintenance dose: 100 to 400 mg orally once a day Comments: -May increase dose at weekly, or longer, intervals. -Doses above 400 mg per day have not been studied.

Usual Adult Dose for Angina Pectoris:

Initial dose: -Metoprolol succinate extended release tablets: 100 mg orally once a day Maintenance dose: 100 to 400 mg per day.

Usual Adult Dose for Congestive Heart Failure:

Metoprolol succinate extended release tablets: 25 mg orally once a day (12.5 mg orally once a day in patients with more severe heart failure); double dose every 2 weeks to highest tolerated dose or up to 200 mg orally once a day

Usual Pediatric Dose for Hypertension:

Metoprolol succinate extended release tablets: 6 Years or Older: Initial dose: 1 mg/kg orally once a day (not to exceed 50 mg orally once a day) Maximum dose: 2 mg/kg (or 200 mg) orally once a day

Warnings

You should not use Toprol-XL if you have a severe heart block (greater than first degree), sick sinus syndrome without a pacemaker, severe circulation problems, severe heart failure, a history of slow heart beats that caused fainting, or if you are allergic to Toprol-XL or metoprolol.

What other drugs will affect Toprol XL

Tell your doctor about all your current medicines. Many drugs can interact with Toprol-XL, especially:

any other heart or blood pressure medications, especially digitalis, clonidine, diltiazem, verapamil, quinidine, propafenone, and others;

epinephrine (Epi-Pen);

an antidepressant, especially monoamine oxidase (MAO) inhibitors (including isocarboxazid, rasagiline, selegiline, phenelzine, transcypromine, and methylene blue injection) and selective serotonin reuptake inhibitors (SSRIs) including fluoxetine, paroxetine and others; or

an ergot medicine--dihydroergotamine, ergonovine, ergotamine, or methylergonovine; or

This list is not complete and many other drugs may interact with metoprolol succinate. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

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