SABCS: Adding Camrelizumab to Neoadjuvant Chemo Beneficial in TNBC

Follow Drugslib on

Medically reviewed by Drugs.com.

By Elana Gotkine HealthDay Reporter

FRIDAY, Dec. 13, 2024 -- The addition of camrelizumab to neoadjuvant chemotherapy improves pathological complete response for patients with early or locally advanced triple-negative breast cancer, according to a study published online Dec. 13 in the Journal of the American Medical Association to coincide with the annual San Antonio Breast Cancer Symposium, held from Dec. 10 to 13 in San Antonio.

Li Chen, M.D., from the Fudan University Shanghai Cancer Center, and colleagues examined the efficacy and adverse events of camrelizumab plus chemotherapy versus placebo plus chemotherapy as neoadjuvant therapy in a randomized, phase 3 trial involving 441 patients with early or locally advanced triple-negative breast cancer. Patients were randomly assigned to receive camrelizumab 200 mg or placebo combined with chemotherapy every two weeks (222 and 219 patients, respectively).

The researchers found that pathological complete response was achieved in 56.8 and 44.7 percent of patients in the camrelizumab-chemotherapy and the placebo-chemotherapy groups, respectively (rate difference, 12.2 percent). Adverse events of grade 3 or higher occurred in 89.2 and 83.1 percent of patients in the camrelizumab-chemotherapy and placebo-chemotherapy groups, respectively, in the neoadjuvant phase; serious adverse events occurred in 34.7 and 22.8 percent, respectively; and fatal adverse events occurred in 0.9 percent of those in the camrelizumab-chemotherapy group.

"The benefits of camrelizumab-chemotherapy with respect to pathologic complete response were generally consistent across subgroups," the authors write.

This study was supported by Jiangsu Hengrui Pharmaceuticals, which manufactures camrelizumab.

Abstract/Full Text (subscription or payment may be required)

Editorial (subscription or payment may be required)

More Information

Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.

Source: HealthDay

Posted : 2024-12-14 12:00

Read more

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Popular Keywords