Generic name: Hepatitis B Adult Vaccine
Drug class: Viral vaccines

Usage of PreHevbrio

Hepatitis B is a disease of the liver that is spread through blood or bodily fluids, sexual contact or sharing IV drug needles with an infected person, or during childbirth when the mother is infected. Hepatitis causes inflammation of the liver, vomiting, and jaundice (yellowing of the skin or eyes). Hepatitis can lead to liver cancer, cirrhosis, or death.

The hepatitis B vaccine is used to help prevent this disease in adults.

This vaccine helps your body develop immunity to the disease, but will not treat an active infection you already have.

Vaccination with hepatitis B vaccine is recommended for all adults who are at risk of getting hepatitis B. Like any vaccine, the hepatitis B vaccine may not provide protection from disease in every person.

PreHevbrio side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Keep track of all side effects you have. If you need a booster dose, you will need to tell the vaccination provider if the previous shot caused any side effects.

PreHevbrio may cause serious side effects. Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • seizure-like muscle movements; or
  • fever, swollen glands.
  • Common side effects of PreHevbrio may include:

  • headache;
  • muscle pain, tenderness, or weakness;
  • tiredness; or
  • redness, pain, swelling, or a lump where the shot was given.
  • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report vaccine side effects to the US Department of Health and Human Services at 1 800 822 7967.

    Before taking PreHevbrio

    Hepatitis B vaccine will not protect against infection with hepatitis A, C, and E, or other viruses that affect the liver. It may also not protect against hepatitis B if you are already infected with the virus, even if you do not yet show symptoms.

    You should not receive this vaccine if you have ever had a life-threatening allergic reaction to any vaccine containing hepatitis B.

    Tell your doctor or vaccination provider if you have or have ever had:

  • lived with someone or had sexual contact with people infected with hepatitis B virus;
  • diabetes, HIV or AIDS;
  • used drugs injected into a vein;
  • lived or worked in a facility for developmentally disabled people;
  • worked in healthcare or public safety or being exposed to blood or body fluids;
  • traveled to areas where hepatitis B is common;
  • lived or worked in a correctional facility;
  • being a victim of sexual abuse or assault;
  • hepatitis C, chronic liver disease; or
  • kidney disease (or if you are on dialysis).
  • This vaccine may need to be postponed or not given at all if you have:

  • an allergy to yeast;
  • an allergy to latex; or
  • weak immune system (caused by disease or by using certain medicine).
  • You can still receive a vaccine if you have a minor cold. In the case of a more severe illness with a fever or any type of infection, wait until you get better before receiving this vaccine.

    Tell your doctor if you are pregnant or breastfeeding.

    If you are pregnant, your name may be listed on a pregnancy registry to track the effects of this vaccine on the baby.

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    How to use PreHevbrio

    This vaccine is given as an injection (shot) into a muscle. A healthcare provider will give you this injection.

    The hepatitis B vaccine is given in a series of 2 to 4 shots. The subsequent shots are usually given 1 month and 6 months after the first shot.

    Your individual vaccination schedule may be different from these guidelines. Follow your doctor's instructions or the schedule recommended by your local health department.

    Be sure to receive all recommended doses of this vaccine, or you may not be fully protected against disease.

    This vaccine can affect the results of certain medical tests. Tell any doctor who treats you if you recently received the hepatitis B vaccine.


    Becoming infected with Hepatitis B is much more dangerous to your health than receiving this vaccine.

    You should not receive another dose of this vaccine if you had a life threatening allergic reaction after the first shot.

    Tell your doctor if you use other medicines or have other medical conditions or allergies.

    What other drugs will affect PreHevbrio

    Before receiving this vaccine, tell your vaccination provider about all other vaccines you have recently received.

    Other drugs may affect this vaccine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.


    Every effort has been made to ensure that the information provided by is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. information has been compiled for use by healthcare practitioners and consumers in the United States and therefore does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise.'s drug information does not endorse drugs, diagnose patients or recommend therapy.'s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of information provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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